标签： 上海后花园龙凤

Cell Stem Cell： dopaminergic progenitor cells derived from human embryonic stem cells in the treatment of Parkinson’s disease

Original biological world

Written by Cong Wang

Edit Wang Duoyu

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Cell therapy is considered to be very suitable for treating Parkinson’s disease (PD) because its pathogenesis is relatively simple and characterized by localized degeneration of dopaminergic neurons in the substantia nigra compacta of the midbrain. In animal experiments and human experiments, transplanting human fetal ventral midbrain tissue or cells has been proved to help restore motor function.

However, these results are often inconsistent, which highlights the need for improved cell therapy programs to ensure that a sufficient number of well-defined midbrain dopaminergic (mDA) neurons are produced and standardized cell preparation and transplantation procedures are adopted.

Recent technological progress has enabled human pluripotent stem cells (hPSC), such as embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC), to efficiently generate mDA neurons, paving the way for establishing transplantation therapy for Parkinson’s disease based on hPSC. Many studies have shown that when transplanted into animal models of Parkinson’s disease, mDA progenitor cells derived from hPSC are well integrated into the host brain and mature into functional mDA neurons, which significantly improves motor function.

Recently, researchers from Yonsei University School of Medicine published a research paper entitled: preclinical and dose-ranging assessment of HESC-derived dopaminergic prognosticators for a clinical trial on Parkinson’s disease [1].

In this study, high-purity midbrain dopaminergic (mDA) progenitor cells were produced on a large scale from clinical human embryonic stem cells (hESC), and the safety and effectiveness of mDA progenitor cells were verified in vitro and in vivo. MDA progenitor cells improved the disease-related behavior of Parkinson’s disease rat model in a dose-dependent manner. Based on these preclinical research results, the research team obtained the approval of the Korean Ministry of Food and Drug Safety for the phase 1/2a clinical trial of cell therapy for Parkinson’s disease, and started the treatment of 12 patients with Parkinson’s disease.

In May, 2020, researchers at Massachusetts General Hospital reported a groundbreaking study in the New England Journal of Medicine (NEJM) [2]. A Parkinson’s patient who received autologous transplantation of mDA progenitor cells from hiPSC showed stable or improved clinical symptoms 24 months after implantation. Now, this method has been further developed, and the mDA progenitor cells derived from hiPSC and hESC began to enter the early clinical trial stage.

The first step in the clinical application of cell transplantation for Parkinson’s disease is to define the characteristics of cell products comprehensively. It is very important to determine whether cells are produced with clinical grade materials under GMP conditions and whether they meet the expected clinical use standards. Subsequently, preclinical research should produce convincing evidence of curative effect through large-scale animal experiments, and systematically examine long-term safety-related issues, such as toxicity, biological distribution and tumorigenicity. In addition, preclinical research needs to determine the optimal cell dose range for transplantation as a reference for human trials. Most importantly, the whole research design must be meticulous and the results must be evaluated in a fair way. This usually requires cooperation with CRO and extensive discussions with regulators.

This paper describes the process and results of a preclinical study aimed at using midbrain dopaminergic (mDA) neurons derived from human embryonic stem cells (hESC) in human clinical trials to treat Parkinson’s disease.

The cell differentiation method used in this study has been optimized for clinical application to ensure that it meets GMP standards. This optimization method can produce mDA progenitor cells with high purity and low temperature preservation on a large scale, while maintaining strict quality control. A year-long large-scale transplantation study by an independent CRO company using immunocompromised rats showed that the transplanted mDA neurons did not cause tumorigenicity, significant toxicity or ectopic integration outside the injection site. In addition, clinical mDA precursor cells showed therapeutic potential and dosage range, and produced therapeutic effects in toxin-induced semi-Parkinson’s rats. These findings provide the necessary information about the appropriate cell dose for human trials.

Specifically, this paper introduces the method of large-scale extraction of high-purity mDA progenitor cells from clinical grade hESC under strict GMP conditions, and also evaluates the toxicity, biological distribution and tumorigenicity of these cells in immunocompromised rats in facilities conforming to good laboratory practices (GLP). Different doses of mDA progenitor cells were transplanted into the semi-Parkinson’s rat model, and it was observed that there was a significant dose-dependent behavior improvement when the minimum effective dose ranged from 5000 to 10000 mDA progenitor cells. These results provide insights for determining the low cell dose (3.15 million cells) in human clinical trials.

Based on these experimental results, the research team obtained the phase 1/2a clinical trial of cell therapy for Parkinson’s disease approved by the Korean Ministry of Food and Drug Safety, and started the clinical trial of treating patients with Parkinson’s disease.

Paper link:

1. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00401-0

2. https://www.nejm.org/doi/10.1056/NEJMoa1915872

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Peng Qinghua emphasized that     Taking epidemic prevention and control as the most important task at present, we should make concerted efforts to win this war without smoke.

On January 27th, Peng Qinghua, Secretary of the Provincial Party Committee, went to Mianzhou Community, Gongqu Street, Fucheng District, Mianyang City to inspect and supervise the prevention and control of pneumonia infected by novel coronavirus. In the community service center, Peng Qinghua carefully checked the personnel prevention and control system ledger and visited the summary table.

On January 27th, Peng Qinghua, secretary of the provincial party committee, led a team to Mianyang City to inspect and supervise the prevention and control of pneumonia infected by novel coronavirus. He stressed that it is necessary to thoroughly study and implement the spirit of the important speech delivered by the Supreme Leader General Secretary at the Standing Committee of the Political Bureau of the Communist Party of China Central Committee Conference, resolutely implement the various arrangements of the CPC Central Committee and the State Council on epidemic prevention and control, take epidemic prevention and control as the most important task at present, strengthen joint defense and control, prevent and treat the epidemic by groups, resolutely curb the spread of the epidemic, and win this blockade war without smoke.

On January 27th, Peng Qinghua, Secretary of the Provincial Party Committee, went to Mianzhou Community, Gongqu Street, Fucheng District, Mianyang City, to inspect and supervise the epidemic prevention and control work, and made video connection with the returnees from the epidemic areas who were isolated at home to ask about their living conditions and practical difficulties to be solved.

Community is at the forefront of grass-roots governance and the front line of epidemic prevention and control. Peng Qinghua came to Mianzhou Community, a "10,000-person community" under the jurisdiction of Gongqu Street in Fucheng District, to inspect and supervise the implementation of joint prevention and control. When he looked through the personnel prevention and control system account and visited the summary table of the arrangement in the community service center, the staff said that "they have been on duty all day and checked the people coming and going in the epidemic area door by door". Peng Qinghua affirmed this and made video connection with the returnees in the epidemic area who were isolated at home to ask about their living conditions and practical difficulties that need to be solved. Peng Qinghua said: General Secretary of the Supreme Leader and the CPC Central Committee attach great importance to the prevention and control of epidemic situation and are very concerned about people’s lives, health and safety. On the first day of the Lunar New Year, the General Secretary of the Supreme Leader presided over the Standing Committee of the Political Bureau of the Communist Party of China Central Committee meeting to re-study, re-deploy and re-mobilize the epidemic prevention and control work. As long as everyone is firm in confidence, in the same boat, scientific prevention and control, and precise policy, we will certainly win the epidemic prevention and control war. He hopes that the people who observe at home will understand, support and actively cooperate with the epidemic prevention and control work. At the same time, he also requires street community cadres to do a good job in the life service of the people who observe at home, do everything possible to solve their material supply and practical difficulties, and do a good job in psychological counseling so that they can fully feel the warmth of society and have a peaceful and healthy Spring Festival.

The community health service station undertakes the functions and responsibilities of pre-examination and triage of fever patients. Peng Qinghua had a cordial conversation with the family doctor who worked there, and asked in detail about emergency duty, diagnosis and treatment, and health knowledge propaganda during the festival. He pointed out that rural areas, communities and families are the focus of current epidemic prevention and control. It is necessary to implement grid and carpet management, adopt information technology, carry out full coverage investigation, dynamically grasp the number and flow direction of people from high-risk areas, strictly implement the system of isolated observation at home, prevent the epidemic from being imported, spread and exported, and be a good "gatekeeper" for people’s health. The prevention and control of epidemic situation is closely related to the life safety of every resident, and every resident can also play a role. It is necessary to guide urban and rural people to develop good health habits, enhance their awareness of self-protection, go out less, wash their hands frequently, wear masks, and do not participate in group dinners and gatherings, and pay attention to avoiding cross-infection among family members.

On January 27th, Peng Qinghua, secretary of the provincial party committee, went to Mianyang City Center for Disease Control and Prevention to inspect and supervise the epidemic prevention and control work, and learned about the reserve and deployment of medical protective masks, disinfectants, logistics support equipment and other materials in the medical emergency materials warehouse.

On January 27th, Peng Qinghua, secretary of the provincial party committee, went to Mianyang CDC to inspect and supervise the epidemic prevention and control work, and listened to the report on the epidemic prevention and control work in Mianyang.

In Mianyang City Center for Disease Control and Prevention, located in Mianyang High-tech Zone, Peng Qinghua walked to the medical emergency materials warehouse to learn about the storage and deployment of medical protective masks, disinfection drugs, logistics support equipment and other materials, listened to the report on epidemic prevention and control in Mianyang City, and visited and sympathized with medical workers. Peng Qinghua emphasized that Mianyang is the second largest city in our province, and it is also the throat of going north to Sichuan. Life is more important than Mount Tai, epidemic situation is the command, and prevention and control is the responsibility. The municipal party committee and municipal government must shoulder the responsibility of prevention and control, keep the safety of the masses in mind, fully implement the deployment requirements of the CPC Central Committee, the State Council and the provincial party committee and government, and earnestly fulfill the responsibility, responsibility and responsibility of defending the land. It is necessary to reserve epidemic prevention materials through various channels, increase market supply, and strive to meet the needs of the people, especially to give priority to the needs of frontline medical personnel. It is necessary to strengthen publicity and guidance, respond to social concerns in a timely manner, solve doubts and doubts in a timely manner, and clear up rumors in time to create a good environment for scientific and orderly prevention and control. The epidemic situation is an examination question, so cadres at all levels should answer it well. Everyone should stick to their posts and take the lead, practice their initial mission in the front line of epidemic prevention and control, and resolutely protect people’s health and life safety.

Provincial leaders Wang Minghui and Wang Yihong, responsible comrades of relevant departments directly under the provincial government participated in the inspection and supervision. (Reporter   Zhang Shoushuai   Photography   Ouyang Jie)

Did anyone inject it？ Answers to three questions about the falsification of rabies vaccine production records for human use

　　CCTV News:Following the announcement issued by National Medical Products Administration on July 15th that Changchun Changsheng Bio-freeze-dried rabies vaccine for human use was produced with false records, on the morning of 16th, Changsheng Bio-announced that all batches of freeze-dried rabies vaccine for human use were being recalled within the validity period.

　

　　Changsheng Bio announced that at present, Jilin Food and Drug Administration has recovered Changchun Changsheng’s GMP Certificate, and Changchun Changsheng has stopped the production of rabies vaccine as required. All batches of products involved in this flight inspection have not yet left the factory and gone on sale, and all products have been effectively controlled. In order to ensure the safety of medication, Changchun Changsheng is recalling all batches of freeze-dried rabies vaccine for human use within the validity period. According to the monitoring of adverse reactions of the rabies vaccine by Changchun Changsheng in recent years, no adverse reactions caused by product quality problems were found.

　　Changchun Changsheng will strictly implement the requirements of the regulatory authorities, actively cooperate with the regulatory authorities to carry out a comprehensive self-examination of the production and quality control system, take effective measures in time to eliminate hidden dangers in production quality, and seriously strengthen quality control.

　　Changchun Changsheng deeply apologized for the occurrence of this incident. Changchun Changsheng will closely follow the progress of the incident and actively cooperate with National Medical Products Administration, Jilin Food and Drug Administration and other relevant regulatory authorities to carry out follow-up work.

　　Has anyone injected the vaccine? This batch has not yet left the factory.

　　For the public, the most concerned question is: has anyone injected this batch of rabies vaccine? According to the announcements made by National Medical Products Administration and the companies involved, all the products involved in this inspection have not yet left the factory and gone on sale, and all the products have been effectively controlled.

　　Several major questions have attracted much attention.

　　To pay attention to several major questions that have attracted much attention in this incident.

　　How is fraud exposed?

　　First of all: How was the vaccine problem discovered? According to the announcement issued by National Medical Products Administration on July 15th, the reason for finding the problem was "to carry out flight inspection on Changchun Changsheng according to clues".

　　What is "flight inspection"

　

　　Also: So what is "flight inspection"?Flight inspection is actually a surprise inspection with strong confidentiality and high efficiency. Especially for the inspection of reporting, compared with the previous follow-up inspection that notified the inspected enterprises in advance, flight inspection is a powerful means to break local protection, expose and crack down on hidden rules of the industry, and severely punish violations of laws and regulations.

　　What records are fraudulent? Under investigation.

　

　　The other thing is, what problems have you found?National Medical Products Administration’s notice said that it was found that the company’s production of freeze-dried rabies vaccine for human use had serious violations of the good manufacturing practice, such as falsification of records. So which records in the production process are falsified? It is still under investigation. However, at present, Jilin Food and Drug Administration has withdrawn the GMP Certificate of this enterprise, which means that the freeze-dried rabies vaccine for human use applied by this factory has been discontinued.

　　At present, National Medical Products Administration has sent a special inspection team to Jilin to supervise the investigation and disposal. We will continue to pay attention to the relevant survey results.

Super lycra retro style! Panasonic SLR L1 plunged 500!

　

　　As an indispensable brand of digital camera, Panasonic’s Lycra lens is loved by consumers, and many friends are also very concerned about the news that it has cooperated with Lycra to launch SLR. Recently, Panasonic’s first SLR L1 has landed in the Beijing market, and its appearance adopts the unique appearance of Lycra camera, and it has been introduced after improving its function and handling. The difference is that Panasonic hopes to make L1 a digital SLR product full of Lycra’s retro taste. Although it is transplanted with the core technology of Olympus E-330, it looks like the classic model LC1 (Digitlux 2). The reason why L1 is worth looking forward to is that its appearance is stable and atmospheric, and its overall appearance jumps out of the ordinary digital SLR camera, with a strong Leica paraxial M series feeling. More importantly, Panasonic L1 has a Leica-certified professional lens group as a strong support, which is very attractive to traditional camera users and Lycra fans with nostalgic plots. The price of L1 has remained unchanged at 19,500 since its listing. Today, the editor learned that the price of L1 has dropped by 500 to 19,000 today, and interested friends can take a look.

model
price
Merchant telephone
Business address

　　　Panasonic DMC-L1

　19000　　　

82539237　

Room 1511B, 15th floor, Science & Trade Building A

松下L1
Panasonic L1　　Tuku　　Evaluation and measurement　　On altar　　Place of purchase

松下L1
Panasonic L1

松下L1
Panasonic L1

　　The L1 fuselage has a volume of 146x87x77mm and a net weight of 530g, which is slightly larger than FZ30 when held in your hand. The fuselage adopts aluminum alloy metal shell, and a layer of non-slip plastic concave-convex surface is wrapped around part of the fuselage, which enhances the stability of the machine. L1, like Ogilvy E-330, uses a Live MOS sensor with 7.5 effective pixels, making it the second digital SLR camera in the world that can take real-time screen shots. In the future, L1 and Olympus E-series SLR products will be compatible with Zuiko Digital and Leica 4/3 system lenses, with a magnification ratio of 2 (equivalent to 35mm camera).

松下L1
Panasonic L1

　　L1 machine back layout, the machine uses a 2.5-inch LCD screen with 207,000 pixels. There are white balance, ISO, flash and EV adjustment on the left side of the screen, and buttons for picture browsing, screen display setting, depth of field preview and deletion on the right side.

松下L1
Panasonic L1

　　L1′ s built-in flashing light has two extension modes. In addition to the "Z"-shaped two-stage expansion, this flashing lamp can also open only one section of the rotating shaft as shown in the figure below, and can be emitted towards the ceiling for light supplement.

松下L1
Panasonic L1

松下L1
Panasonic L1

松下L1
Panasonic L1

松下L1
Panasonic L1

　　L1′ s right shoulder function turntable is quite different from ordinary SLR products. In addition to metering mode and continuous shooting mode, the entire turntable located on the shutter key only provides shutter speed options, which can be selected from 60-1/4000 seconds. L1 didn’t provide the P/A/S/M full manual control key on the turntable, but set the shutter and aperture adjustment options on the right shoulder turntable and the lens respectively (there will be a close-up introduction of the lens on the next page of the article). When L1 is connected to a 4/3 lens without an aperture dial, such as an Ogilvy Zuiko lens, one of the FUNC. keys next to the dial will automatically default as an aperture adjustment button. When Panasonic’s own lens is usually used, the two FUNC. keys can be set by the user as shortcut keys for function menu adjustment.

松下L1
Panasonic L1

松下L1
Panasonic L1

　　This time bundled with DMC-L1, it is this LEICA D VARIO-ELMARIT lens with a focal length of 14-50mm and a maximum aperture of F2.8-3.5, and supports Panasonic’s unique MEGA O.I.S optical hand shock prevention technology. The official has announced that due to factors such as production capacity, the initial L1 and the matching Lycra sleeves will not be sold separately. Because the conversion ratio of focal length of 4/3 system is 2, the actual focal length is equivalent to 28-100mm of 35mm camera when connected to use. When the user needs to adjust the aperture size, he only needs to press the button in the red circle in the figure with his left thumb, so as to avoid the user’s misoperation of the aperture dial when adjusting the focal length. When users need to take photos in P mode, they only need to adjust the shutter and aperture dial to Auto at the same time.

松下L1
Panasonic L1

　　L1 only supports SD card, and is compatible with Panasonic’s newly released high-speed SD HC memory card.

松下L1
Panasonic L1

　　DMW-BL14 lithium battery with a capacity of 1400 mA is adopted. According to CIPA standard, 450 photos can be taken when the lens with MEGA O.I.S function is used, and the number of photos can be increased when matched with other lenses.

Pacific computer network today’s quotation, live room parameter list（2007.05.29）
Model:
DMC-L1
Effective pixels:
7.5 million pixels
Optical zoom factor:
Depending on the lens
Sensor type:
CMOS sensor, Live MOS
Sensor size:
17.3×13.0mm,4/3 inch
LCD screen size:
2.5 inches
Storage medium:
MMC card, SD card, SDHC card

[Reference price]:Panasonic DMC-L1　 19,000 yuan　(29 May 2007)
[Tel]: 010-82539237　
[Business Address]: Room 1511B, 15th Floor, Building A, Science and Trade
[Quotation inquiry]:Beijing digital camera quotation　Beijing Panasonic Digital Camera Quotation

New choice of ocean network exposure BYD Seal 06 declaration map

　　[car home domestic spy photos] A few days ago, we got a brand-new model of BYD-(|) from the latest issue of official website of the Ministry of Industry and Information Technology. As a brand-new model, it adopts the latest design style and is very fashionable as a whole. Judging from the size, the new car, as a model between Seal DM-i and destroyer 05, should also be in the price range between them.

　　Friendly reminder:I hope enthusiastic netizens can photograph the spy photos of your new car and send them to our corresponding mailbox: diezhao@autohome.com.cn. I look forward to your letter and become a member of the "spy".

Home of the car

　　In terms of appearance, the new car adopts the brand-new design concept of BYD Ocean Series. The closed front shape is matched with LED light groups with corners on both sides and the sharp cooling openings on both sides of the front enclosure, which presents a very dynamic style as a whole.

Home of the car

　　On the side of the car body, the new car adopts a slightly slip-back design, which looks very compact and round as a whole. In the rear part, the new car adopts the popular penetrating taillight group, and the taillights on both sides adopt a drop-shaped design, which, together with the transparent lamp shell, makes the new car show a fashionable and dynamic attribute. The rear enclosure uses a double-layer and double-color design, which shows the sharpness of the rear diffuser and further enhances the dynamic atmosphere of the new car.

Home of the car

　　　In terms of body size, the length, width and height are 4830/1875/1495mm and the wheelbase is 2790mm respectively. In terms of power, the car adopts a plug-in hybrid power system consisting of a 1.5L engine of BYD472QC model, in which the maximum power of the engine is 74 kW. At the same time, according to the contents of the announcement, Seal 06 will provide two power versions depending on the battery capacity and motor power. Among them, equipped with a 10.08kWh battery version, the pure electric cruising range of the Ministry of Industry and Information Technology (WLTC) is 60km；; With the 15.874kWh battery version, the pure electric cruising range of the Ministry of Industry and Information Technology (WLTC) can reach 90km. In addition, the EHS electric hybrid system has a pure electric driving experience and fuel consumption performance, and its quietness is excellent. According to reliable sources, Seal 06 will be equipped with BYD’s new generation of DM-i super hybrid technology, which is expected to bring new breakthroughs in energy efficiency. Under NEDC working conditions, the fuel consumption per 100 kilometers is less than 3L. For more information about the new car, we will continue to pay attention. (Text/car home Zhouyi)

Mercedes-Benz mercedes benz c-class Beijing area significantly reduced the price, with the lowest offer of 234,800! Limited time promotion

In the [Easy Car Beijing Local Car Market Promotion Channel], we sorted out the ongoing
Preferential activities. As a car that has attracted much attention, the current discount rate of mercedes benz c Class is still very amazing, with the highest discount rate even reaching 100,000 yuan and the lowest starting price only being 234,800 yuan. You can win a larger discount rate by clicking the "Inquiry" button in the quotation form. If you are looking for a practical and affordable car, you may wish to learn about the mercedes benz c-class discount.

First, look at the appearance of mercedes benz c-class. The front face of mercedes benz c-class accords with consumers’ aesthetics, and the grille is designed with multiple frames, which looks more atmospheric. The front headlights are soft, which improves the level. The car is equipped with LED daytime running lights, headlight height adjustment, automatic opening and closing, adaptive far and near light, delayed closing and so on. Coming to the side of the car body, the size of the car body is 4882 mm * 1820 mm * 1461 mm. The car uses sharp lines, and the car side feels very sharp. With large-sized thick-walled tires, it gives people a very fashionable and dynamic feeling. Looking back, the rear of the car echoes the front face, the taillights show a dignified design style, and the exhaust pipe adopts a bilateral single-outlet design, and the overall layout is impressive.

Coming into the car, the mercedes benz c-class interior looks very elegant and full of fighting atmosphere. The steering wheel of the car is very in line with the interior style. It is equipped with the functions of manual steering wheel up and down+front and rear adjustment, steering wheel shifting and so on, which is full of design sense. Take a look at the central control, with the 11.9-inch touch-sensitive LCD central control screen, which makes the interior design quite layered and spiritual. Let’s take a look at the dashboard and seats again. The dashboard design is remarkable, and the information reading is simple and clear. The car adopts imitation leather seats, which are wide and thick, and the overall comfort and wrapping are not bad.

Mercedes benz c Class is an eye-catching luxury car. Its design is elegant and exquisite, and its lines are smooth, giving people a calm and atmospheric feeling. The interior is also excellent, the materials are exquisite, the workmanship is fine, and the details are in place. During the driving process, mercedes benz c class has very strong power performance, fast and stable acceleration, and smooth shifting, which brings extraordinary control experience to drivers. In addition, its spacious space has also been highly praised, and it has performed well in both riding and storage. Generally speaking, the mercedes benz c Class is an excellent model with features, performance and practicality, which is worthy of consumers’ choice.

Liu Qingyun exposes the secret of not cheating for 15 years： all relying on acting to release his desires


yule.sohu.com
True
World Wide Web

https://yule.sohu.com/20130929/n387419194.shtml
Report
1921
Liu Qingyun revealed the secret of not cheating for 15 years [Global Network Comprehensive Report] Academy Award Best Actor Liu Qingyun and his wife Guo Aiming have been married for 15 years

Jaguar XFL price reduction information in Jinhua area! Discount 170,000, act quickly

On the Autohome Jinhua Promotion Channel, this luxury sedan is running a high-profile promotion. At present, the car series is going through an unprecedented price reduction promotion in Jinhua area, with a staggering maximum discount of 170,000 yuan. Excitingly, the starting price has been reduced to a minimum of 239,800 yuan, which is a very attractive car purchase opportunity. If you are interested in the Jaguar XFL, be sure to click the "Check the car price" button in the quotation form to keep abreast of the latest offers and strive for the highest car purchase discount.

金华地区捷豹XFL降价信息！优惠17万，赶快行动

The Jaguar XFL embodies a luxury-sporty aesthetic, with elegant and powerful fronts and streamlined body lines that highlight the essence of British luxury. The iconic grille is chrome-plated and leopard-print-like, with LED headlights that not only enhance the visual impact, but also ensure driving safety. The overall style blends modern technology with classic elegance, and the XFL can attract the attention of everyone, whether on the city street or on the quiet country lane.

金华地区捷豹XFL降价信息！优惠17万，赶快行动

As a luxury car, the Jaguar XFL’s body design is streamlined and elegant, showing the unique charm of the British brand. The body length reaches 5102mm, the width is 1890mm, the height is 1456mm, and the wheelbase reaches 3100mm, providing sufficient support for the interior space. The front and rear wheel tracks are 1605mm and 1609mm respectively, ensuring driving stability and comfort. What is particularly striking is its tire specifications. The front and rear use 245/40 R19 high-performance tires, with exquisite wheel rim design, which not only enhances the driving performance, but also adds to the visual dynamic feeling of the vehicle.

金华地区捷豹XFL降价信息！优惠17万，赶快行动

The interior design of the Jaguar XFL is based on luxury and sophistication, showing the style of British elegance. In the spacious cabin, the steering wheel is made of leather to provide a comfortable grip, and supports manual and electric up and down + front and rear adjustment to ensure the driver’s personalized needs. The 11.4-inch central control screen shows the sense of technology, integrating multimedia systems, navigation and phone functions to bring convenient intelligent experience to the driver. The seats are made of high-end leather, and the main and passenger seats are equipped with front and rear, backrest, high and low adjustment and waist support. The front seats are also equipped with heating function to provide passengers with a comfortable ride experience. In addition, the car is also equipped with USB and Type-C ports, including two ports in the front row, as well as wireless charging function of mobile phones, to meet the needs of modern drivers for convenient connection and charging. The driver’s seat also has an electric memory function to enhance driving comfort. The overall interior design not only focuses on practicality, but also does not lose luxury and comfort, creating a distinguished in-car environment for drivers and passengers.

金华地区捷豹XFL降价信息！优惠17万，赶快行动

The Jaguar XFL is powered by a 2.0T turbocharged engine with a maximum power of 184 kilowatts and a maximum torque of 365 Nm, providing 250 horsepower output. This engine, combined with an 8-speed manual transmission, provides the driver with a smooth and efficient driving experience.

To sum up, the Autohome owner is full of praise for the appearance of the Jaguar XFL, saying that the young and fashionable design of this model just caters to the aesthetic needs of current consumers. The low-lying design of the body not only adds a sense of movement, but also resembles the elegance and power of a cheetah, making the driver the focus of attention on the road. This evaluation undoubtedly highlights the success of the Jaguar XFL in terms of exterior design, and also indicates its good response and continued appeal in the market.

＂Mr. Bao came to Taiwan＂, Hu Ge went to Taiwan to participate in literary and artistic exchanges

Hu Ge arrived in Taiwan today (12th) to participate in cultural exchange activities. As soon as he appeared at the airport, he was welcomed by fans with high-decibel screams. When asked about his feelings of coming to Taiwan, he happily responded: "So kind! I miss you so much!" Asked what kind of food would you like to eat? Hu Ge replied loudly: "Rice noodles!"

At the airport, surrounded by fans and the media, Hu Ge did not forget to remind everyone to be careful. On the way to the parking lot, a male fan in a wheelchair followed, and he kept reminding them to be careful. At this time, the male fan rushed in front of him and raised his mobile phone to take a photo. He also stopped and raised his hand to look at the camera and smiled, satisfying the fan’s request.

Hu Ge will attend the "Dialogue Youth" film and television experience exchange event at the Songshan merchandise park in Taipei City. His last visit to Taiwan was in 2018, when he was the guest of honor for the Golden Horse Awards.

Hu Ge previously played the leading role of A Bao in Wong Kar-wai’s first TV series "Flowering Flowers", which set off a trend of chasing dramas on the Internet. The drama will be broadcast on My Video ** in Taiwan on June 14. Taiwanese media reported under the title "Flowering Flowers" Bao has always come to Taiwan! Hu Ge was invited to attend the’Dialogue Youth ‘lecture ", saying that since the broadcast of" Flowering Flowers ", the topic of Weibo has exceeded 11.50 billion in reading, and the topic of Douyin has reached 19.10 billion. It has also swept major awards and won the honor of" Drama of the Year "." Now Taiwanese audiences finally look forward to the official broadcast of the drama in Taiwan, and they are happy that the leading actor Hu Ge will also come to Taiwan. " Originally, the heroine Tang Yan (playing Miss Wang) was also going to Taiwan, but Tang Yan’s studio said that it had hit the schedule, so only Hu Ge went to communicate with Taiwanese youth.

It is reported that cross-strait films are gradually resuming exchanges, including Zhang Yi, who starred in "Hurricane", and actor Wei Chen, who will bring the film "Three Battalions" to Taiwan for exchanges. Director Dong Runnian of the phenomenal comedy "Annual Meeting Can’t Stop!", which has raised the topic of workplace this New Year’s Day, and star Da Peng will also go to Taiwan.

(Yangcheng Evening News · Yangcheng School Comprehensive Surging News, Straits Guide, etc.)

Looking at the N side of Stephen Chow, he spoke for himself： Actually, I am an actor


Zhou Xingchi endorses himself: In fact, I am an actor

　　　 Movie Network News Zhou Xingchi has always been a figure with different opinions, and the outside world’s evaluation of him is high in the sky and low in the nose. This situation can’t help but remind people of movies, it seems that all the characters who are so good that they are hard to reach have several three-dimensional sides, and everyone can’t see through them at a glance. June 22 is Zhou Xingchi’s birthday, and we try to restore a real Xingye from his life trajectory and different people’s evaluation of him.

Stephen Chow’s self-endorsement: Actually, I’m just an actor

　　　 We often refer to Stephen Chow as Star, we know that he is the well-deserved "king of comedy", and we regard him as the originator of comedy. But he did not fall into the film industry with these halos from the beginning. He started from a walk-on and gradually achieved today’s status. If you look through his external achievements and status to see his original intention and essence, then it is like the line he often says in autobiographical films: "Actually, I am just an actor."


Stephen Chow when he was the host


Zhou Xingchi took a group photo with Huang Rihua in the 83rd edition of "Archery"

Heaven doesn’t follow people’s wishes, a difficult career starts

　　　 Stephen Chow’s dream of being an actor originated from his love for Bruce Lee. Every time he did an interview show, he would say that he put all his enthusiasm into studying Bruce Lee. Bruce Lee was his spiritual pillar, and even today, it is still the same. He wanted to be Bruce Lee so much that even if he had no money to eat, he would buy sandbags to practice martial arts at home.

　　　 It’s still a cliché story. In 1982, Stephen Chow took Tony Leung, who had a good relationship with his sister, to apply for the TVB artiste training class. As a result, Stephen Chow failed, but Tony Leung, who was not interested in acting, was admitted. Finally, Stephen Chow entered the night section of the training class with the help of Qi Meizhen, and has been playing tricks since graduation. Everyone is most familiar with the training targets of Song Bingyi and Mei Chaofeng in the 83 version of "The Legend of the Shooting Condor Hero". Chow, who was hopeless in acting, finally became the host of the children’s program for four years, and this host’s opportunity still took over the class of Leung Chaowei, because at that time Leung Chaowei had already become famous in Hong Kong City because of his role as Wei Xiaobao. And you can see a little bit of that life.

The next page: Zhou Xingchi’s life turning point