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Cell Stem Cell： dopaminergic progenitor cells derived from human embryonic stem cells in the treatment of Parkinson’s disease

Original biological world

Written by Cong Wang

Edit Wang Duoyu

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Cell therapy is considered to be very suitable for treating Parkinson’s disease (PD) because its pathogenesis is relatively simple and characterized by localized degeneration of dopaminergic neurons in the substantia nigra compacta of the midbrain. In animal experiments and human experiments, transplanting human fetal ventral midbrain tissue or cells has been proved to help restore motor function.

However, these results are often inconsistent, which highlights the need for improved cell therapy programs to ensure that a sufficient number of well-defined midbrain dopaminergic (mDA) neurons are produced and standardized cell preparation and transplantation procedures are adopted.

Recent technological progress has enabled human pluripotent stem cells (hPSC), such as embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC), to efficiently generate mDA neurons, paving the way for establishing transplantation therapy for Parkinson’s disease based on hPSC. Many studies have shown that when transplanted into animal models of Parkinson’s disease, mDA progenitor cells derived from hPSC are well integrated into the host brain and mature into functional mDA neurons, which significantly improves motor function.

Recently, researchers from Yonsei University School of Medicine published a research paper entitled: preclinical and dose-ranging assessment of HESC-derived dopaminergic prognosticators for a clinical trial on Parkinson’s disease [1].

In this study, high-purity midbrain dopaminergic (mDA) progenitor cells were produced on a large scale from clinical human embryonic stem cells (hESC), and the safety and effectiveness of mDA progenitor cells were verified in vitro and in vivo. MDA progenitor cells improved the disease-related behavior of Parkinson’s disease rat model in a dose-dependent manner. Based on these preclinical research results, the research team obtained the approval of the Korean Ministry of Food and Drug Safety for the phase 1/2a clinical trial of cell therapy for Parkinson’s disease, and started the treatment of 12 patients with Parkinson’s disease.

In May, 2020, researchers at Massachusetts General Hospital reported a groundbreaking study in the New England Journal of Medicine (NEJM) [2]. A Parkinson’s patient who received autologous transplantation of mDA progenitor cells from hiPSC showed stable or improved clinical symptoms 24 months after implantation. Now, this method has been further developed, and the mDA progenitor cells derived from hiPSC and hESC began to enter the early clinical trial stage.

The first step in the clinical application of cell transplantation for Parkinson’s disease is to define the characteristics of cell products comprehensively. It is very important to determine whether cells are produced with clinical grade materials under GMP conditions and whether they meet the expected clinical use standards. Subsequently, preclinical research should produce convincing evidence of curative effect through large-scale animal experiments, and systematically examine long-term safety-related issues, such as toxicity, biological distribution and tumorigenicity. In addition, preclinical research needs to determine the optimal cell dose range for transplantation as a reference for human trials. Most importantly, the whole research design must be meticulous and the results must be evaluated in a fair way. This usually requires cooperation with CRO and extensive discussions with regulators.

This paper describes the process and results of a preclinical study aimed at using midbrain dopaminergic (mDA) neurons derived from human embryonic stem cells (hESC) in human clinical trials to treat Parkinson’s disease.

The cell differentiation method used in this study has been optimized for clinical application to ensure that it meets GMP standards. This optimization method can produce mDA progenitor cells with high purity and low temperature preservation on a large scale, while maintaining strict quality control. A year-long large-scale transplantation study by an independent CRO company using immunocompromised rats showed that the transplanted mDA neurons did not cause tumorigenicity, significant toxicity or ectopic integration outside the injection site. In addition, clinical mDA precursor cells showed therapeutic potential and dosage range, and produced therapeutic effects in toxin-induced semi-Parkinson’s rats. These findings provide the necessary information about the appropriate cell dose for human trials.

Specifically, this paper introduces the method of large-scale extraction of high-purity mDA progenitor cells from clinical grade hESC under strict GMP conditions, and also evaluates the toxicity, biological distribution and tumorigenicity of these cells in immunocompromised rats in facilities conforming to good laboratory practices (GLP). Different doses of mDA progenitor cells were transplanted into the semi-Parkinson’s rat model, and it was observed that there was a significant dose-dependent behavior improvement when the minimum effective dose ranged from 5000 to 10000 mDA progenitor cells. These results provide insights for determining the low cell dose (3.15 million cells) in human clinical trials.

Based on these experimental results, the research team obtained the phase 1/2a clinical trial of cell therapy for Parkinson’s disease approved by the Korean Ministry of Food and Drug Safety, and started the clinical trial of treating patients with Parkinson’s disease.

Paper link:

1. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00401-0

2. https://www.nejm.org/doi/10.1056/NEJMoa1915872

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National Health Commission important reminder! When respiratory diseases enter the high season, you need to know these things.

　　At present, with the continuous winter in various places, respiratory diseases have entered a period of high incidence. National Health Commission held a press conference on 26th to introduce the prevention and treatment of respiratory diseases in winter in China and answer reporters’ questions.

National Health Commission important reminder! When respiratory diseases enter the high season, you need to know these things.

　　01

　　Recently, acute respiratory diseases have continued to rise.

　　Related to the superposition of multiple respiratory pathogens.

　　At the press conference, Mi Feng, a spokesperson for National Health Commission, said that monitoring showed that influenza was the main infectious disease of respiratory tract recently, and rhinovirus, mycoplasma pneumoniae, respiratory syncytial virus and adenovirus were also caused. It is believed that the recent increase of acute respiratory diseases in China is related to the superposition of various respiratory pathogens.

　　1. All localities should scientifically co-ordinate medical resources, implement a graded diagnosis and treatment system, adjust their strength across disciplines and hospitals, give play to the role of medical associations, and improve the diagnosis and treatment ability of general infections and the efficiency of severe identification and referral;

　　2. Efforts should be made to increase the number of related consulting rooms and treatment areas, appropriately extend service hours, strengthen drug supply security, give play to the role of traditional Chinese medicine, and maximize the ability to receive consultations and the standardization of diagnosis and treatment;

　　3. It is necessary to disclose and continuously update the information of medical institutions that provide services such as pediatrics and fever clinics to the society in a timely manner, and give play to the role of Internet hospitals and primary health care institutions to facilitate the people to seek medical treatment in an orderly manner nearby;

　　4. Do a good job in epidemic prevention and control in schools, kindergartens, nursing homes and other key crowded places, and reduce personnel flow and visits.

　　National Health Commission reminded the public that it is necessary to adhere to the sanitary habits of wearing masks, ventilation and washing hands frequently, and advocate key groups such as "one old and one small" to actively vaccinate relevant vaccines; When you have respiratory symptoms, you should be well protected, keep a social distance, and avoid cross-infection in your family and unit.

　　At present, the health departments of all provinces in China have published the information of local medical institutions that can provide pediatric diagnosis and treatment services on the official website and government WeChat platform, and will update them in time.

　　02

　　Recent respiratory infectious diseases

　　Different age groups have different main pathogens.

　　Wang Huaqing, chief expert of immunization program of China CDC, introduced at the press conference that according to the results of multi-pathogen monitoring, the main pathogens prevalent in different age groups of respiratory infectious diseases in recent years are different:

　　Influenza virus and rhinovirus are the main types of people aged 1~4;

　　Influenza virus, mycoplasma pneumoniae and adenovirus are the main population aged 5~14.

　　Influenza virus, rhinovirus and Covid-19 are the main types of people aged 15-59.

　　People aged 60 and above are mainly influenza virus, human metapneumovirus and common coronavirus.

National Health Commission important reminder! When respiratory diseases enter the high season, you need to know these things.

　　03

　　Vaccination for respiratory diseases in the elderly

　　What are the precautions?

　　Vaccination against influenza is an effective means to prevent influenza, which can reduce the risk of influenza and serious complications. The old people were vaccinated with influenza, pneumococcus and other respiratory diseases, and the results showed that it was safe and effective. In the process of inoculation, attention should be paid to:

　　1. Those who have a clear history of severe allergy to vaccines to be vaccinated or to be vaccinated, or vaccines with similar technical routes, cannot be vaccinated again;

　　2. If you have a chronic disease and are in an acute episode, you need to slow down the inoculation and consider vaccination after your health is stable;

　　3. Vaccination doctors should strictly implement the vaccination work norms. If there is any health damage or other reaction suspected to be related to vaccination after vaccination, they should seek medical advice in time and report.

　　04

　　Children have fever and cough.

　　There are no signs of aggravation, so you don’t have to go to the hospital repeatedly.

　　The child has a respiratory disease, and the main symptoms are fever and cough.

　　Wang Quan, chief physician of Beijing Children’s Hospital, National Children’s Medical Center, said in an interview with CCTV reporter that fever and cough are almost inevitable after respiratory infection. As long as there are no signs of aggravation in this process, there is no need to go to the hospital repeatedly.

　　"The purpose of taking antipyretics is not to lower the body temperature to normal, but to increase the comfort of children and let them spend the fever period safely and comfortably. All diseases have a recovery process, especially for diseases with respiratory virus infection, which usually takes 3 to 5 days to recover. "

　　In addition, Wang Quan said that parents are usually not advised to give their children antitussive drugs by themselves. Cough is a protective reflex of the human body. It is good for children to relieve their illness by coughing it out because of throat discomfort or secretions in the respiratory tract. If cough seriously affects children’s sleep, parents can relieve it by atomization under the guidance of a doctor.

　　05

　　How to prevent respiratory diseases in winter?

　　In winter, respiratory infectious diseases enter the season of high incidence. Influenza, adenovirus, respiratory syncytial virus, mycoplasma pneumoniae … What are the symptoms of different respiratory diseases? How to judge which pathogen is infected? How to prevent it? What kind of situation requires immediate medical attention? Poke the map to understand, collect and spare ↓↓↓↓

National Health Commission important reminder! When respiratory diseases enter the high season, you need to know these things.

　　06

　　Drinking Radix Isatidis to prevent colds from hurting the body.

　　Afraid of catching a cold, can you drink Radix Isatidis to prevent it?

　　The answer is: no!

　　In the absence of disease symptoms, if Radix Isatidis is taken as a preventive medicine for a long time and in large doses, it may make our gastrointestinal function disorder and increase the metabolic burden of liver and kidney.

[Editor in charge:

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Drooling! The top Sichuan cuisine ＂Songyun Banquet＂ has 32 dishes. What do the Sichuan cuisine masters say？

Sichuan Online Reporter Zhang Hongxia Photography Ji Yong

Zhang Yuanfu (first from right), the third generation descendant of Rongleyuan, was interviewed.

At 14: 00 on December 25, the "Song Yun Banquet" has been going on for more than two hours, and the banquet process of 8 links and 32 dishes has been completed — — The banquet system of Sichuan cuisine, which originated from Rongyuan a hundred years ago, received the joint tasting and comments of the "Chengdu Famous Banquet" Sichuan cuisine masters at Songyunze, a famous restaurant.

Rose beef

The masters of Sichuan cuisine are all famous, and Song Yunze’s reputation is growing day by day. What kind of comments will the masters leave after the "Song Yun Banquet" is over? Sorting out the viewpoints, we found that the discussion of the masters collided with important debates about Sichuan cuisine, such as old and new, integrity and innovation, persistence and integration. How to clarify the relationship and establish a binary balance? The opinions of the masters are all wonderful.

From left to right, the masters of Sichuan cuisine are Zhang Zhongyou, Lan Qijin, Wang Kaifa, Lu Chaohua and Xiao Jianming.

Comments: Who are the masters of Sichuan cuisine?

Mr. Zhang Zhongyou, a national first-class cook and a master of Sichuan cuisine, stepped forward from restaurants such as Chengdu Nuli Meal and entered the United Nations delegation in China.

Mr. Lu Chaohua, the executive chef of Jinjiang Hotel, a five-star hotel, and a national first-class cook, has led a team to international food competitions such as the United States, Brazil and France on behalf of the country and achieved good results;

There is a second generation descendant of the century-old Rongyuan, a veteran master of Sichuan cuisine in China, and Mr. Wang Development, who was sent by the state as a chef of Rongyuan American branch for 8 years in the early 1980s;

There is Mr. Lan Qijin, deputy general manager of Jinniu Hotel, the State Guesthouse, who participated in the production of state banquets for many times and visited with leaders. In the mid-1980s, he served as the head chef in the Chinese restaurant in Dü sseldorf, Germany.

Mr. Xiao Jianming, the second generation descendant of Yourong Paradise, the national first-class chef, the head chef and director of Chengdu Piaoxiang old Sichuan restaurant.

Experts in the audience, including Mai Jianling, President of Sichuan Cuisine Association, Zhao Yipin, Secretary-General, Lan Mei, Sun Peike and other media food experts, are all judges and appraisers of Chengdu famous banquet, and they are also witnesses of the first complete appearance of Songyun Banquet in the industry in the traditional way of Sichuan cuisine.

Fish mutton tripe

Tracing back to the source: Is Rongparadise new or old?

About Song Yunze, since its establishment three years ago, it has always been a maverick in the food industry.

Walk alone because you stick to — — Adhere to the pattern, techniques and taste essence of modern Sichuan cuisine pioneered by Rongyuan a hundred years ago; Walking alone is because of opinions — — The so-called innovation that people don’t understand and are not familiar with the origin of Sichuan cuisine is a disorderly innovation without "roots", and the task at the present stage is to "adhere to tradition and innovate cautiously".

What was the glory paradise like a hundred years ago? About this source, in the master’s summary and comment session, it is restored and revealed bit by bit.

Cold white meat

The banquet format of "Song Yun Banquet" has been recognized. From the ancient menu design to the complete display of the banquet process, to the matching of utensils and fine meal sharing; From the exquisite taste of 12 cold dishes to 9 hot dishes, it is very humanistic and friendly; From the skills of "cooking coarse dishes carefully" in home-cooked dishes such as Sichuan style pork and white meat with garlic paste, to the practical improvement of traditional dishes such as lion’s head and fish and mutton tripe; From the patient hanging and stewing of three fresh noodles, abalone with liver oil and other kung fu dishes, to the various methods of making soup and kimchi … … All the details and even the whole highlight the care and consideration of tasting experience, nutrition collocation and facial features enjoyment.

Chengdu snacks fangyougao

This kind of high-quality banquet, which is both from the Republic of China and engraved in the present, has been unanimously recognized by well-informed masters.

Comments by Lan Qijin, a master of Sichuan cuisine: meticulous, meticulous and classic. He said: "We can see that there are adjustments and optimizations in every dish, and there are innovations, but the overall techniques and tastes retain the essence of tradition."

Master Zhang Zhongyou said: "Sichuan cuisine has a history of thousands of years. Modern Sichuan cuisine has developed for a hundred years, and it has become one of the eight major cuisines in China. It must have its deep roots and connotations, and it is not shoddy. This banquet pays attention to the color, smell and flavor, and the size of the utensils is very suitable. It is really a beautiful enjoyment. "

Mai Jianling, president of the Provincial Food Association, returned to the story of Rongyuan to experience the "new and old" of the source. She said that when many people heard that Song Yunze cooked traditional Sichuan cuisine, they thought it was very outdated and rustic, but in fact, the dishes served at the Song Yunze Banquet were not old at all, but had a feeling that tradition was in line with fashion. Rong Paradise is like this.

"For example, today is Christmas. Rongyuan developed a dish at that time, wrapped it in net oil and cooked it with barbecued pork, and then divided it into small portions for everyone to eat. This is not an old dish, it is an innovative dish completely according to the season, and it is ‘ The typical practice of "eating in western food" shows that Rongleyuan’s food concept is very smart and keeps pace with the times. "Mai Jianling’s words triggered the recognition of the masters.

Master Wang Development is not only the judge of "Chengdu Famous Banquet", but also the founder of Song Yunze. He spoke about the new and old understanding that "Song Yunyan" wanted to convey — —

"Old, that is, tradition, is a foundation, a basic skill, and the root of where we come from. Only by understanding where we come from can we better know where we are going."

"Innovation means innovation. It is definitely impossible to hold the old things unchanged. It is necessary to keep up with the changes of the times and make reasonable and moderate optimization, instead of making it unrecognizable and new. It is necessary to know why and where it is new, so that the combination of the old and the new can be more stable and further."

Looking back: What is the main reason for the evolution of Sichuan cuisine?

According to Wang Development, after the founding of the People’s Republic of China, the development of Sichuan cuisine experienced ups and downs. After the reform and opening up, Sichuan cuisine experienced a period of low tide, especially in the 1990s, when it was completely attacked by Cantonese cuisine, and its position was completely lost. "It is only in these years that Sichuan cuisine has gradually adjusted back and developed, but it is very chaotic. As an old man in the catering industry, we feel sad and worried." Wang Kaifa took action with the masters of Sichuan cuisine who shared the same feelings. In 2015, 91 masters of Sichuan cuisine initiated the establishment of a seminar on the traditional skills of Sichuan cuisine masters, determined to stop Sichuan cuisine from slipping into a spicy trend.

Master Xiao Jianming caught the conversation and asked a question: "Why can the development of Sichuan cuisine stand out from the traditional Sichuan cuisine and change into various cuisines?"

He went on to say: "Behind this is the diversification of demand brought about by the changes of the times. Today’s Chengdu is a mega-city with a population of over 20 million. When it was just liberated, Chengdu had a population of only 5 million, and the overall social needs were very different. "

For example, he said, the salt-help dishes, which are famous for their spicy, oily and salty tastes, "will definitely not survive" in Chengdu, where there are only 5 million locals. However, when there are hundreds of thousands of people from southern Sichuan in Zigong and other places among the 20 million urban population, there will be a demand market. The catering industry is a field with a high degree of marketization. If there is demand, there will naturally be supply, just like Hunan cuisine and Cantonese cuisine, it is because of demand that they can survive and develop.

"Generally speaking, it is the expansion of the city that brings new market opportunities. This is a very natural economic phenomenon, which is understandable, but we should also strengthen the inheritance and promotion of traditional Sichuan cuisine." He said that the prosperity of fine dishes can not be separated from the support of economic development, so Chengdu-Chongqing Corridor has become the main market of Sichuan cuisine, and there will be different types in different places. For example, Chongqing cuisine is a "river and lake cuisine" with heavy taste, which is influenced by macro factors such as local geography, humanities, politics and economy, and can be understood by each other.

In the eyes of other masters, the rise and fall of traditional Sichuan cuisine is closely related to both urban changes and practitioners’ ideas and choices. Traditional Sichuan cuisine was once lost in the evolution of food because it was labor-consuming and time-consuming, which was due to the great times; Nowadays, under a solid model created by Wang Development and Zhang Yuanfu, traditional Sichuan cuisine is getting more and more recognition, which is a kind of feeling and a kind of dedication.

"Although I am 75 years old, I often feel that Sichuan cuisine is profound and profound, and I haven’t learned enough. Sometimes disciples, students and people in the society ask me some questions, and it is difficult to answer them accurately and comprehensively at the moment, so I think Sichuan cuisine should be developed and all of us need to work together." Wang Kaifa’s concluding remarks touched all the gentlemen present and applauded for a while.

Respect for legal affairs： Weibo users leave at a glance. kk’s malicious behavior damages the brand reputation.

Yichexun On December 20,The official of Zunjie Automobile Legal Affairs issued a document, saying that it was concerned that users of "Sina Weibo" had maliciously guided public opinion and deliberately slandered Zunjie Automobile, which had damaged the brand reputation.We immediately reported to the public security organs, and after investigation and evidence collection, the public security organs dealt with their illegal acts according to law.

We are very willing to listen to well-intentioned suggestions from all walks of life, but we will continue to use legal weapons to fight back against false information and malicious slander against Zunjie Automobile on the Internet, and resolutely defend the legitimate rights and interests of Zunjie Automobile and its users.

In this regard, Weibo users "Take a look and go kk "issued an apology statement on Weibo.I slandered Zunjie automobile in Sina Weibo group and comment area through my account "kk at a glance" on Sina Weibo platform (I used the nickname "You are my only kk" and UID:1202632627). I have now realized that my behavior has seriously reduced the social evaluation of Zunjie Automobile, seriously damaged the brand image of Zunjie Automobile and seriously disrupted the public order on the Internet. I know I was wrong. Here, I sincerely apologize to Zunjie Automobile and the public who like Zunjie Automobile. I have deleted the relevant defamatory remarks on the whole platform and tried my best to eliminate the influence.

I solemnly promise that this kind of incident will not happen in the future, and I will never publish anything that may affect the image of Zunjie Automobile, damage the reputation of Zunjie Automobile and hurt the feelings of Zunjie Automobile fans.

Finally, I once again promise that I will surf the Internet in accordance with the law and regulations in the future. Please don’t make rumors, believe in rumors, spread rumors, hype and have no rhythm from the media and netizens, and jointly maintain a good network environment.

IPhone sales decline, Zhengzhou Foxconn national day contraction？ Employee： Only some production lines are working overtime.

　　"National Day is a rare golden working period in a year. Why should we rest?" This holiday, Zhao Fei (pseudonym), who has worked in Zhengzhou Foxconn for nearly five years, is still at the front end of the iPhone16 assembly line. He said that because workers’ salaries and company orders are at a high level at the same time, "almost no one will choose to take a holiday during the National Day".

　　"As in previous years, the salary for the National Day holiday this year is three times that on weekdays." Zhao Fei said that from October 1 ST to October 3 rd, the company paid wages according to the daily three times; From October 4 th to October 5 th, because it belongs to the weekend, it will be paid twice as much as usual; Wages on October 6 and October 7 are the daily level.

　　Before the National Day holiday, domestic consumer electronic products ushered in intensive release. On the mobile phone side, Huawei MateXT tri-folding screen mobile phone, iPhone16, Glory Magic V3 and Meizu Lucky 08 AI appeared one after another; In terms of automobiles, according to incomplete statistics, nearly 50 new cars including Huawei Zhijie R7 and Chery Tiggo 8 PLUS went on the market in September.

　　"I’ve been so busy recently that I’ve been working as soon as I entered the workshop." Li Wei (pseudonym) is in charge of the whole machine test of iPhone16 in an electronics factory in Jiangsu. Because the new machine has just been listed, the factory has added production lines since August and increased the manpower reserve.

　　He said that the factory is a "two-shift" production mode, and he has been working on the night shift for more than a month. He has not been informed to switch to the day shift system, and he is already "tired and dizzy".

　　"Although tired, everyone is generally willing to work overtime for high salary." Li Wei said that during the National Day holiday, high unit salary and high order volume will show a "multiplier effect". "April to August every year is the off-season of sales of consumer electronics. At that time, there were not many orders, and everyone didn’t even have the opportunity to work overtime." Li Wei said that his personal workload has reached the "full production" standard of the factory. "My other partner and I are now testing 12,000 mobile phones every day, with an average of 6,000 mobile phones per person every day."

　　Li Wei said that he can only adjust himself when he is busy. "After entering the workshop for two hours, you can use these two hours to think about all the happy things to neutralize the boring work".

　　IPhone sales fell short of expectations

　　Zhengzhou Foxconn reduces production by reducing recruitment.

　　On September 26th, a report from Morgan Stanley pointed out that the average delivery time of iPhone 16 from booking to today was 14 days, which was the shortest in all cycles in the past five years, which meant that the sales of iPhone 16 series were less than expected. Prior to this, Guo Ming, a well-known analyst, said that the pre-order sales of iPhone 16 series were about 37 million units in the first weekend, which was about 12.7% lower than the sales of iPhone 15 in the same period last year.

　　Another set of data also shows that the iPhone 16 market is in a downturn. Barclays Bank analysts Tim Long and George Wang pointed out in the report that due to lower-than-expected demand, Apple may have cut production of iPhone 16 series in the fourth quarter. The data of spare parts procurement shows that the iPhone 16 series has cut about 3 million units.

　　Canalys data shows that the sales of iPhone 15 series in the second quarter of this year were also lower than expected. Among the iPhones sold in the second quarter, the proportion of four iPhones 15 was 67%, which was less than 79% of the iPhone 14 series in the second quarter of last year, a decrease of more than 10 percentage points.

　　Or affected by the overall decline in iPhone sales, during the National Day this year, Zhengzhou Foxconn was not as busy as in previous years. Zhao Fei said that the factory reserved a batch of manpower in September, and opened the recruitment channel on October 4th, but the recruitment efforts were reduced compared with previous years, "maybe only half the level of previous years", and at the same time, the number of additional production lines this year was not as good as the same period last year.

　　Zhao Fei said that before the National Day, it was generally a stage of "mass production" in factories, and only some production lines were working overtime this year. "The production line responsible for the production of iPhone16 is busy, and the daily working hours of workers are about 11 hours, all week round. The production line responsible for the foreign orders of the iPhone15 series has almost no overtime work. "

　　Changes in working hours have affected the income of some workers. "Workers who are responsible for the production of old models will have their income reduced accordingly with the change of overtime hours." At present, the reward of returning workers is considerable among all workers.

　　Zhao Fei said that Foxconn’s workers are mainly divided into three types: return workers, hourly workers and regular workers. Fee-returning workers refer to workers who join the company within a specific period of time, and they can get a bonus of 7,000-8,000 yuan after the three-month construction period.

　　"On average, the monthly salary of Zhengzhou Foxconn returning workers is about 5,000-6,000 yuan; Hourly workers are workers who are paid according to the working hours. The hourly wage is about 26 yuan, working 8 hours a day, and the overtime hours are not fixed; The remuneration of regular workers is calculated by the basic salary of about 2,200 yuan, plus irregular overtime pay. "

　　The factory has emerged as a "king of rolls"

　　Work 12 hours a day

　　Not all electronics factory workers were paid three times during the National Day.

　　Zhang Hao (a pseudonym), a junior, worked as an intern in a factory in Wenzhou, where she worked as an OEM for Volkswagen, Chery and other car companies, and was responsible for testing some parts. He said that during the holiday, the factory only paid double wages on October 2 and October 3, and the rest of the time was the daily salary level.

　　"Even if you don’t get three times the salary, it won’t affect everyone’s work enthusiasm." Zhang Hao said that after the employment agency and the school provide internship opportunities, they will draw part of the commission from the college students’ labor remuneration. His hourly salary is 16 yuan, and he wants to work overtime during the National Day to increase his income.

　　"April to June is the off-season of the factory every year. At that time, everyone’s average salary was only more than 3,000 yuan. As car companies introduced new cars one after another, a number of’ roll kings’ emerged in the factory, working from 8 am to 10 pm, except for meals. Working for up to 12 hours a day, and going to other working groups to help on rest days." Zhang Hao told the Times Weekly reporter.

　　The increase in orders has caused some workers to "roll up" and brought pressure to some workers.

　　"The impression of the outside world on the assembly line usually stays on the keywords of’ repetition’ and’ boring’. In fact, the workshop is also a small society, especially in the busy stage, and it seems that everyone is more likely to have conflicts." Li Wei said that as the workload increases, the probability of omissions will also increase. "After the omission, it is inevitable to be scolded by the team leader."

　　Liu Ying (not his real name), who is engaged in testing at Foxconn, told Times Weekly that when he is busy, he should maintain a good relationship with his partner and superiors.

　　He said that each station in the factory will roughly assign two workers to cooperate to complete a task. If the partner is inefficient, it will also affect his own rhythm. Liu Ying also said that he prefers night shift to day shift, "because there is no leader to inspect the night shift".

　　Zhao Fei recalled to the Times Weekly reporter that he had always been kind to junior workers, but only once criticized a worker for an omission. As a result, the worker took advantage of the meal break and hid more than a dozen prototypes on the production line. "I have been looking for a week, but I still haven’t found a few."

　　Li Wei told the Times Weekly reporter that although it was the peak of employment, there were also many workers who left the electronics factory during the National Day.

＂Mr. Bao came to Taiwan＂, Hu Ge went to Taiwan to participate in literary and artistic exchanges

Hu Ge arrived in Taiwan today (12th) to participate in cultural exchange activities. As soon as he appeared at the airport, he was welcomed by fans with high-decibel screams. When asked about his feelings of coming to Taiwan, he happily responded: "So kind! I miss you so much!" Asked what kind of food would you like to eat? Hu Ge replied loudly: "Rice noodles!"

At the airport, surrounded by fans and the media, Hu Ge did not forget to remind everyone to be careful. On the way to the parking lot, a male fan in a wheelchair followed, and he kept reminding them to be careful. At this time, the male fan rushed in front of him and raised his mobile phone to take a photo. He also stopped and raised his hand to look at the camera and smiled, satisfying the fan’s request.

Hu Ge will attend the "Dialogue Youth" film and television experience exchange event at the Songshan merchandise park in Taipei City. His last visit to Taiwan was in 2018, when he was the guest of honor for the Golden Horse Awards.

Hu Ge previously played the leading role of A Bao in Wong Kar-wai’s first TV series "Flowering Flowers", which set off a trend of chasing dramas on the Internet. The drama will be broadcast on My Video ** in Taiwan on June 14. Taiwanese media reported under the title "Flowering Flowers" Bao has always come to Taiwan! Hu Ge was invited to attend the’Dialogue Youth ‘lecture ", saying that since the broadcast of" Flowering Flowers ", the topic of Weibo has exceeded 11.50 billion in reading, and the topic of Douyin has reached 19.10 billion. It has also swept major awards and won the honor of" Drama of the Year "." Now Taiwanese audiences finally look forward to the official broadcast of the drama in Taiwan, and they are happy that the leading actor Hu Ge will also come to Taiwan. " Originally, the heroine Tang Yan (playing Miss Wang) was also going to Taiwan, but Tang Yan’s studio said that it had hit the schedule, so only Hu Ge went to communicate with Taiwanese youth.

It is reported that cross-strait films are gradually resuming exchanges, including Zhang Yi, who starred in "Hurricane", and actor Wei Chen, who will bring the film "Three Battalions" to Taiwan for exchanges. Director Dong Runnian of the phenomenal comedy "Annual Meeting Can’t Stop!", which has raised the topic of workplace this New Year’s Day, and star Da Peng will also go to Taiwan.

(Yangcheng Evening News · Yangcheng School Comprehensive Surging News, Straits Guide, etc.)

Kuaishou × Jietu Shanhai ＂Fireworks China Year＂ Micro Variety Explore ＂Dragon＂ Culture and Create Chinese New Year Flavor Marketing

　　The Year of the Dragon in the 2024 lunar calendar is approaching, and how to tell the "dragon" cultural story well has become a problem-solving point for brand marketing. On the occasion of welcoming the Year of the Dragon, Kuaishou collaborated with Jietu Shanhai to create a micro-variety show "Fireworks China Year", and invited cross talk actors Sun Yue and Sun Zizhao to join in. He went to Kunming, Yunnan to appreciate the local folk culture of "dragon" and explore the "dragon" in the intangible cultural heritage.

　　In this unique "journey to find the dragon", "Fireworks China Year" takes users to see the "dragon" inheritance in Chinese culture, and also conveys the brand concept of Jietu Shanhai in the exploration of the customs and culture of welcoming the New Year with great fireworks, and promotes the expansion of the volume of Jietu Shanhai L9.

　　Walk through the Chinese New Year fireworks and explore the cultural heritage of the Chinese "dragon"

　　In the micro variety show "Fireworks China Year" titled by Jietu Shanhai and produced by Kuaishou, the well-known crosstalk actor Sun Yue and his apprentice Sun Zizhao took the Jietu Shanhai L9 with large space, good appearance, fast speed, and 5/7 seats to switch at will. The first stop came to the Long Street Fair in Chenggong District, Kunming City. The long, winding streets like dragons gathered all kinds of food and general merchandise. Catching up with the excitement of preparing New Year’s goods a year ago, Sun Yue and Sun Zizhao felt the pomp of the local market.

　　Through fun game settings, the two guests clocked in to try Yunnan’s local fried potato chips, flower cakes, dried beef and other specialties. Following the guests’ perspective, users learned about Yunnan’s food characteristics and folk customs in the "immersive market" experience.

　　Specialty delicacies are a must for the New Year, and unique folk cultural performances are also an indispensable sense of New Year’s rituals. In Baicao Village, Xishan District, Kunming City, Sun Yue and Sun Zizhao followed the Baicao Village Bai Nationality Women’s Dragon Dance Team and entered the century-old Baicao Dragon Dance Culture.

　　Developed from the sacrificial team of villagers worshiping the gods and praying for good weather and abundant grain, today’s Baicao Village Dragon Dance Team has inherited the performance skills of dragon dance and wishes for people’s better life. During the festival, it shuttles between thousands of households to bring peace to people. Raising the dragon head and swinging the dragon tail, the two guests and the dragon dance team put on the words "Chinese Dragon" and sent a unique Chinese New Year blessing.

　　In addition to the Hundred Herbs Dragon Dance, the intangible cultural heritage culture "Bench Dragon Dance" is also one of Kunming’s characteristic art forms. The unique three-legged bench, wrapped with a dragon body and a dragon head, becomes a "Bench Dragon". The rhythm sounds, and the "Bench Dragon" comes to life in the hands of the performers, dancing in the air, rolling and coiling.

　　Following the non-genetic inheritors of "Bench Dragon", Sun Yue and Sun Zizhao joined the "Bench Dragon" team and presented the "Bench Dragon Dance" with the performers to pray for the New Year. The fun interaction between the guests dispelled the sense of distance between traditional culture and people. Through the joyous interpretation of the guests, users also felt the wonders of folk performance culture such as dragon dance and "bench dragon dance".

　　Traditional cultural connotation activates users emotional resonance, Chinese New Year content empowers brand marketing

　　Combining the multiple elements of Chinese New Year folk customs + regional culture + joy and fun, "Fireworks China Year" brings users a new experience of fireworks New Year with a "journey to find dragons" with a regional style. In addition to the program, Kuaishou also launched the topic of "Fireworks China Year" online, encouraging users to share the fireworks welcome moments in their lives, share laughter, and create a fiery Chinese New Year atmosphere in the Year of the Dragon.

　　Create popular content with micro-variety shows, and set off an interactive craze with hot topics. "Fireworks China Year" integrates a variety of styles of content to release Chinese New Year marketing opportunities for Jietu Shanhai. By presenting scenes such as stocking up on New Year’s goods and families traveling together, "Fireworks China Year" creates real and vivid grass-planting content, helping Jietu Shanhai seize the Chinese New Year marketing hotspots and achieve a loud explosion.

　　In addition, by exploring the regional characteristics of folk culture, "Fireworks China Year" awakens the public’s sense of identity with the traditional "dragon" culture, builds a Chinese New Year custom cultural content marketing position, connects brands and users in a rich Chinese New Year atmosphere, and helps brands achieve full-link marketing demands such as exposure, planting grass, and transformation.

　　Focusing on the taste of the Year of the Dragon is not only a new practice of Kuaishou’s "Fireworks China Year", but also a new incision for Jietu Shanhai festival marketing. As a new energy sequence newly created by Jietu Automobile, Jietu Shanhai pursues zero-distance contact with the audience in brand marketing. Jietu Shanhai L9, which is positioned as "Big Family Big Seven Super Hybrid SUV", starts from the most realistic family car scene during the Spring Festival of the Year of the Dragon, and takes everyone to pass on the fireworks of the Year of the Dragon, enjoy the variety of life, stimulate the potential of the whole people to participate, and empower the content marketing of the models with the cultural connotation of the Chinese New Year festival.

　　In the future, Kuaishou will continue to create more diverse content and activities, focusing on user requests, mining traditional festivals and other ethnic characteristics, and bringing new content marketing to the brand. (Li Li)

Oaks Air Conditioning x Wuhan Industrial and Trade Home Appliances： Helping Four Seasons Fresh Air Conditioning Enter More Families

　　On May 24th, the "Fresh Air China, Fresh Oxygen Four Seasons" Fresh Air Conditioning National Popularization Action and Four Seasons Fresh Air Conditioning Wuhan First Tasting Meeting jointly organized by Oaks Air Conditioning and Wuhan Industry and Trade Home Appliances were successfully held. Representatives of Oaks Air Conditioning brand, Wuhan Industry and Trade Home Appliances, invited guests, and cross-circle experts attended together, enjoying the natural beauty in the pastoral scenery, sharing the direction of cooperation, and exploring a wild fresh oxygen journey. As the protagonist of this tasting session, Oaks Four Seasons Fresh Air Conditioning officially announced its first listing in Wuhan. It will use the core product proposition of "45 ° independent new trend, 1 hour whole house fresh oxygen" and multiple preferential propositions to popularize fresh air conditioners in more families and help more users enjoy fresh oxygen breathing and embrace the fresh air of life.

　　Soft and fresh oxygen fresh air, life is always new in all seasons

　　At the scene of this tasting session, Oaks Four Seasons Fresh Air Conditioning, once unveiled, triggered a warm discussion among the guests and an exchange and discussion on the fresh air air conditioning market. As the latest masterpiece of Oaks Air Conditioning, which has been painstakingly researched and developed for two years, Four Seasons Fresh Air Conditioning adopts a 45 ° independent new trend, integrating the three core products of rapid fresh air, smart mother and baby air, and HEPA-level purification and sterilization. It can achieve 1-hour whole house fresh oxygen replacement, and is committed to bringing users healthy and comfortable, all-season new high-quality air solutions.

　　Unlike other fresh air conditioners in the industry or side or front air outlets, Oaks Four Seasons Fresh Air Conditioning innovatively adopts a 45 ° air outlet method with a fresh air volume of 40m 3/h, and is equipped with an independent fresh air module, which not only supports the independent opening of the fresh air function, but also can achieve faster air supply speed and longer air supply distance under the same air volume, allowing the fresh air to cover the whole house faster. It can replace the air in the whole house in about 1 hour, fully interpreting the "rapid replacement of fresh air".

　　Thanks to the original internal and external dual-conducting microporous technology and 8,335 cloth holes, the wind speed of Oaks Four Seasons Fresh Air Conditioning is as low as 0.1m/s, even sensitive people such as mothers and babies can blow with confidence. In addition, under the function of intelligent temperature control sensing and frequency control constant temperature, it can sense room temperature changes and achieve accurate temperature control of ± 0.5 ° C. It intelligently switches between the two air modes of "Breeze Sense" and "Light Wind Sense", creating "Smart Mother and Baby Wind" with heart.

　　In addition to that, the Oaks Four Seasons Fresh Air Conditioning is also equipped with a HEPA-level purification module, which can effectively filter harmful substances. The PM2.5 purification rate is as high as 98.4%. In addition, the fifth-generation automatic washing technology, 56-degree high-temperature sterilization, and six-fold washing purification better ensure the fresh air supply and protect the user’s respiratory health.

　　Empowering end point retail, helping to popularize fresh air

　　2022 is Oaks air conditioning "focus on products to empower customers, direct users", all-round boost product power, channel power, marketing power of the year, in addition to focusing on innovative products such as four seasons fresh air air conditioning, Oaks air conditioning will also focus on "empowering customers", through deep cultivation of new retail, adhere to the net batch strategy, pull through the online store and brick and mortar store promotion integration, to partners multi-faceted support, empowering end points.

　　Wuhan Industrial and Trade Home Appliances, as the largest home appliance chain business enterprise in Hubei Province, is an important partner of Oaks Air Conditioning in central China, with Wuhan as the center. Since the launch of the cooperation, the two sides have created extraordinary results in the field of home appliance retail. In order to popularize fresh air conditioning to more families, the two sides jointly launched multiple preferential propositions, including cleaning services, ten-year warranty, exclusive gifts, price-break discounts, etc., aiming to help more consumers easily enjoy the fresh air environment of fresh oxygen breathing all year round, so that life is always new.

　　Oaks Four Seasons Fresh Air Conditioning not only changes the fresh air quickly, but also has a soft and clean air outlet. It helps users enjoy a high-quality home environment with "45 ° independent new trend, 1 hour of fresh oxygen in the whole house". This time, Oaks Air Conditioning and Wuhan Industrial and Trade Home Appliances have launched multiple promotions, which will provide consumers in Wuhan and its surrounding areas with sincere choices and promote the popularization of fresh air air conditioning. On May 28th, Oaks Air Conditioning "Oxygen is Wild Enough, Fresh Oxygen Music Festival" and "Four Seasons Fresh Air Live Buying Ceremony" will be grandly opened online, so stay tuned!

　　[Advertising]

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Another 1.4 billion yuan was invested, and Xiaomi revealed the recent progress in building cars.

Author | Cui Qiuyang

Edit | Chapter Ripple

Xiaomi Auto is one step closer to its official debut.

On August 29th, Xiaomi Group released the results announcement for the second quarter and the first half of 2023, and held a conference call.

On the whole, although the overall revenue decreased in the second quarter, the gross profit, operating profit and adjusted net profit all ushered in year-on-year growth, of which the operating profit and net profit reached 4.04 billion yuan and 5.14 billion yuan respectively, both of which increased by more than 130% year-on-year.

And published together with various financial data,There is also a set of data about Xiaomi’s automobile business: 1.4 billion yuan of research and development expenses.

Financial Information of Xiaomi Group in the Second Quarter of 2023

In this regard, Lu Weibing, partner of Xiaomi Group, president of the group and chairman of the brand Committee, revealed that thanks to the efficient use of funds, "this figure is even less than we expected."

Since the official announcement of the car, according to the public financial data, Xiaomi Group has invested more than 5.5 billion yuan in the automobile business, from supply to manufacturing, to products and sales..

The time plan for mass production in the first half of 2024 is getting closer and closer. What is the specific progress of Xiaomi Automobile??

01

Acknowledging the summer test, the progress of building a car exceeded expectations.

Although in the financial report meeting, Lu Weibing made it clear that the news about Xiaomi Automobile was not authorized by the company and could not be disclosed more, but a small part of the news was released.

He clearly admitted that Xiaomi Automobile had conducted a summer test in Xinjiang, and the progress was very smooth..

On August 19th this year, Lei Jun, chairman of Xiaomi, took a group photo on social media, with the IP belonging to Xinjiang, and the banner held by everyone in the photo read "Fight for Xiaomi Automobile".

Recently, Lei Jun released the Weibo in Xinjiang

This has aroused widespread concern from the outside world, and it has been speculated that Xiaomi Automobile is very likely to conduct a road test in Xinjiang in summer, and Lei Jun personally leads the team.

"Two days ago, I and Lei Zong sent Weibo’s IP to show in Xinjiang at the same time, and everyone was wondering whether we went to Xinjiang to take part in the summer test, which is true. Our summer test should be said to be very smooth. " In response to this incident, Lu Weibing gave a positive answer.

He added:"Our goal of mass production and sales in the first half of 2024 has not changed. Now everything is going very smoothly, which can be said to have exceeded our original expectations and plans.. "

According to Lu Weibing,Xiaomi Automobile currently has nearly 3,000 R&D personnel.. "When Xiaomi Automobile chose to enter the automobile industry from the beginning, we made all the layouts from the perspective of’ a century-old industrial change’ and with the strategic goal of’ Xiaomi will enter the top five global electric vehicle brands in the future’. Based on this layout, we adopted the whole process of self-research, and almost all aspects of our first car were self-developed by Xiaomi. "

Due to the choice of self-built factories and full-stack self-research, Lu Weibing said frankly,Xiaomi automobile has adopted a very over-investment approach."It can be said that in order to ensure the smooth progress of the first car, we have invested a lot. We will also disclose relevant investment every quarter, which can be used as a reference for Xiaomi’s investment in automobiles. Of course, from the perspective of cash flow, it may be faster. "

02

Everything seems to be ready, from manufacturing to channels.

Although Lu Weibing didn’t disclose much, we can still find out how Xiaomi’s car-making business is progressing from the aspects of supply side, manufacturing side, product side and sales side.

First of all, look at the supply of parts.

In the era of new energy vehicles, the most important part is the battery, regardless of the cost or the function of the whole vehicle.

Contemporary Amperex Technology Co., Limited is rumored to be one of the suppliers of power batteries for Xiaomi Automobile.

Earlier, according to Interface News, Xiaomi Automobile has confirmed that Zhongchuang Singapore Airlines and Contemporary Amperex Technology Co., Limited are the primary and secondary power battery suppliers at this stage. BYD, which was previously speculated by the outside world, is not on the supply chain list.

However, some insiders told Cybercar that,The power battery supplier of Xiaomi Automobile has already been determined, and it will still adopt the combination of Contemporary Amperex Technology Co., Limited and BYD, in which Contemporary Amperex Technology Co., Limited will supply ternary lithium batteries to Xiaomi Automobile and BYD will supply lithium iron phosphate batteries..

No matter which battery manufacturer’s products are used, it is certain that Xiaomi will adopt a multi-supplier model in the supply of power batteries from the very beginning..

On the one hand, it has absorbed the experience of the predecessors of the new energy main engine factory in the previous two years. In 2022, many new energy OEMs adopted a single supplier model for some parts and components, and all of them were cut off under the impact of the epidemic, resulting in that they could not produce and deliver on time even if they had more orders, which not only reduced the capacity utilization rate, but also caused orders to be unsubscribed by users.

On the other hand, although Xiaomi Automobile is already a big traffic user before it is officially listed, what is always seen in the automobile industry is the sales volume, not the topic heat. Xiaomi Automobile, which has no mass production delivery experience, does not have much bargaining power in front of suppliers.

After the introduction of the multi-supplier model, coupled with the obvious oversupply of power batteries, Xiaomi Automobile has more initiative.

In the supply of other key components, we can spy on Xiaomi’s capital layout..

Among them, in terms of lidar, Xiaomi has invested in four lidar manufacturers, including Hesai Technology, Innovusion Tudatong, Beixing Photon and Sagitar Juchuang, through Xiaomi Group, Xiaomi Investment and Shunwei Capital associated with Lei Jun; In the autonomous driving solution, Xiaomi also invested in Zongmu Technology, Geometry Partners, Smart Walker and Momenta, and even acquired the autonomous driving company Deepmotion, taking its accumulated technology in intelligent driving perception, decision-making, planning and control as the basis for self-research.

On the manufacturing side, the Yizhuang Phase I factory built by Xiaomi Automobile is nearing completion, and its annual production capacity is expected to reach 150,000-200,000 vehicles.. It is reported that Yizhuang factory has also started to recruit workers in large quantities for more than 100 job vacancies in painting, welding and battery workshops.

Yizhuang will become the future R&D and manufacturing center of Xiaomi Automobile.

But in 2023, production qualification is the most important thing for car companies in the manufacturing end.

After the National Development and Reform Commission and the Ministry of Industry and Information Technology successively issued the Regulations on the Administration of Newly Built Pure Electric Passenger Cars and the Regulations on the Administration of New Energy Vehicle Manufacturers and Products Access, it is difficult to enter the new energy market in 2023. Both the self-traveler and Jidu were subject to the new regulations, or regretted leaving temporarily, or turned to seek a new car-making model.

But recently,According to the report of Reuters, Xiaomi Automobile has removed this obstacle and obtained relevant vehicle-making qualifications, but the reason and process for Xiaomi Automobile’s specific qualification are unknown..

In terms of products,According to the public information, the first two products of Xiaomi Automobile will be marked with Tesla Model 3 and Model Y respectively, and it is likely to provide a battery version of 101kWh, and there is also a high probability that at least an optional version of lidar will be provided..

Regarding the most important selling price,According to insiders, the starting price of Xiaomi’s first car will probably drop below 200,000 yuan and reach the level of 170,000 yuan..

Judging from the summer test performance of Xiaomi Automobile exposed by Hu Zhengnan, a partner of Shunwei Capital Investment, in Weibo a few days ago,In the high temperature environment, Xiaomi automobile can give a performance of 8.8kWh/100km. For comparison, the reference data of Model 3 energy consumption given by Tesla is 12.6kWh/100km..

On the whole,With the starting price of 170,000 yuan, plus 101kWh battery, lidar version and 8.8kWh/100km energy consumption, Xiaomi’s first product is already quite competitive..

Hu Zhengnan released the energy consumption performance of Xiaomi automobile in summer test in his Weibo.

Finally,existOn the sales side, Xiaomi is likely to learn from Huawei, select some of its own more than 10,000 channel stores and upgrade them to user centers. Even if only one tenth of the stores are upgraded, there are about 1,000, which is also the level of the head of the domestic new energy main engine factory..

According to the public information, Xiaomi Automobile has started the site selection of the delivery center, requiring the candidate venue to provide at least 120 parking spaces, and the construction area should not be less than 3,000 square meters.

Besides,Lei Jun also revealed two small messages at this year’s Xiaomi annual conference:At present, almost all smart electric vehicles are equipped with wireless charging; The perception system of the second generation robot dog iron egg is somewhat similar to the current intelligent car perception system..

03

Can you go public on an auspicious day? Xiaomi automobile not only owes Dongfeng.

From supply to manufacturing, from products to sales, Xiaomi Automobile seems to be fully prepared for the launch of the first product.

However, Xiaomi Automobile is really ready for everything, only owing to the east wind. Can it be listed on an auspicious day? It doesn’t seem to be.

After the arrival of the new energy wave, the situation of the whole automobile industry can be said to be changing rapidly, and no matter how many and prudent plans, they can’t keep up with the changes.

Some netizens broke the news and photographed four Xiaomi car test cars in Xinjiang.

From the price point of view,Xiaomi’s first car product is selected as the benchmark Model 3. If the starting price really comes to 170,000 yuan, it means that it is 30,000 yuan cheaper than the current Model 3. This price is very attractive to consumers..

But the mantis catches cicadas, and the yellowbird is behind. On August 28th, Tucki announced that it would lower the price threshold of intelligent electric vehicles to 150,000 yuan. Tucki officially announced that it will acquire Didi’s existing and highly-completed pure electric platform, and launch 150,000-yuan B-end +C-end products on this platform, among which the C-end products will be empowered by Tucki’s roll-up structure and XNGP intelligent assisted driving system.

In this way,Although Xiaomi car products are cheaper than Model 3, their advantages are not obvious compared with Tucki..

Not only that, thanks to the gambling agreement signed with Didi, Tucki’s upcoming 150,000-yuan products will not worry about sales. There is a high probability that there will be a sales scale of 100,000 vehicles every year, while Xiaomi needs to fight alone to fight our way out.

In addition,Xiaomi should also be prepared to "support one child for the whole family" at the beginning of the business..

Xiaomi’s second-quarter financial report data shows that the overall gross profit margin of Xiaomi in this quarter, as well as the gross profit margin of smart phone business and IoT and consumer products business, all reached new highs, reaching more than 13%.

However, from Wei Xiaoli to Zero Run, Nezha, Ai ‘an, etc., all the new OEMs in recent years started with negative gross profit margin and huge losses. Li Bin, founder and CEO of Weilai Automobile, even admitted that "it is impossible to build a car without 40 billion yuan".

Once it officially enters the market, I am afraid that Xiaomi’s auto business will not only face losses, but also drag down the financial data of Xiaomi Group and even affect the performance of the Group in the secondary market.

Xiaomi has rich experience in hardware manufacturing, and the existing sales channel network is also one of the advantages.

But on the bright side,Thanks to the origin of its own mobile phone manufacturer, Xiaomi may also save a lot of costs in terms of large-scale production, sales network layout and some R&D expenditures..

Among them,Different from Wei Xiaoli, Xiaomi has the experience of large-scale hardware manufacturing and mass delivery, and there should be no "productivity hell" in the initial stage of vehicle delivery..

In addition, as mentioned above, Xiaomi Automobile can choose to upgrade its existing offline stores instead of relocating them to deploy its sales network.

What’s more, in order to ensure the competitiveness of the mobile phone business, Xiaomi has laid out the AI ? ? big model technology.Lu Weibing also revealed in the conference call that AI will definitely be combined with "Little Love Classmate" (Xiaomi’s artificial intelligence assistant) in the future. After the release of automobile products, Xiaomi’s accumulated technology in human-computer interaction and AI big model can also be directly adapted to the car end, without extra time and effort to develop related functions for the intelligent cockpit from scratch..

All in all, thanks to its years of experience in the field of mobile phones and IoT, Xiaomi Automobile can be said to have a considerable degree of software and hardware R&D and manufacturing capabilities, not to mention being born with a golden spoon, but even so, in the increasingly cruel automobile market, Xiaomi Automobile is still a long way from getting a "real ticket".

The last ＂battle＂ before autonomous driving, Zhiji Automobile released the ＂Roadmap for the landing of smart driving products in the next 3-5 years＂

[Global Network Automobile Comprehensive Report] (August 16, 2023, Beijing) Recently, two Tsinghua alumni-Guo Hui, deputy CTO/ of Zhiji Automobile/chief scientist of intelligent driving, and Cao Xudong, CEO of Momenta, a global head intelligent driving algorithm player, joined hands with Tsinghua University Institute of Vehicles and Transportation.subdecanalProfessor Shengbo Eben Li, held in Tsinghua Science Park."IM AD DAY Zhiji Automobile Intelligent Driving Conference Tsinghua" exchanged and discussed with the guests on many topics such as technical route, experience standard and development trend before the end of automatic driving..

At the event, Professor Shengbo Eben Li of Tsinghua University shared "Safety Challenges and Technical Progress of Self-driving Cars", which was highly summarized."Data-driven" gives autonomous driving a "safe" technological evolution path. Guo Hui, chief scientist of Zhiji automobile intelligent driving, reviewed.TomojiAfter 2 years, the head player has been driving for 9 years.The technological evolution track of has reachedHuman driving safety3.2 timesUser experience of smart driving products; And published it."Roadmap for the landing of Zhiji automobile intelligent driving products in the next 3-5 years", announced that it will be this year.In October, the public beta of "IM AD City NOA" was officially launched, and it entered the "urban NOA era" in synchronization with the global head players..Cao Xudong, CEO of Momenta, analyzed in detail "Based on DDOD, DDLD, D.L.P artificial intelligence model,IM AD intelligent driving will be fully data-driven, and most scenes will be automatically driven in the next 3-5 years.",towards the end of automatic driving!

TomojiAfter two years of friendship and nine years of intellectual driving,In 2025, it will enter the era of Door to Door.

Coming soonThe NOA beta of the city opened in October means thatZhiji automobile YongIn 2 years (Zhiji brand was released in 2021), it completed the accumulation of head players in other industries for 9 years, and constantly set a new record of "the fastest mass production of intelligent driving products" in the industry..

From the road map, the futureIn 3~5 years, Zhiji Automobile will start the intelligent driving products to accelerate the running, and the intelligent driving products such as high-precision map NOA, urban NOA and commuting mode will be intensively launched:

· "Go to the high-precision map NOA", IM AD will open the public beta in September;

· "City NOA", which started internal testing in April this year, is progressing smoothly and will start public testing in October;

· "Commuting mode" is expected to quickly cover 100+ cities nationwide in 2024;

In 2025, IM AD will enter the era of Door to Door.

Achieved3.2 times the human driving safety, and the intelligent driving experience is superior to the industry’s head level.

At the same time of rapid evolution, high-standard intelligent driving experience is the highest value appeal of Zhiji automobile. Zhiji automobile intelligent driving assistance systemIM AD not only surpasses most human drivers in safety, traffic efficiency and road game ability, but also provides users with an experience obviously superior to the industry standard..

Especially the safety, at present, Zhiji automobile has achieved human driving safety.3.2 times of intelligent driving. The statistical results of actual driving data show that at present, the number of collision accidents per million kilometers of IM AD is 0.6, which is far lower than the number of collision accidents per million kilometers driven by human beings, which provides a solid security guarantee for the user experience of man-machine driving. IM AD’s safety class false braking frequency is less than once per million kilometers, which is 5 times better than the industry head standard.

On the performance experience,IM AD’s delivery standard is also strict, which exceeds the level of the top players in the industry, whether it is "driving performance" such as lane change efficiency, driving center performance, driving fluency and driving comfort, or "parking performance" such as parking space recognition ability, parking success rate and parking fluency. The success rate of IM AD lane change is as high as 98%, the uncomfortable deceleration is only 1.3 times per thousand kilometers, and the success rate of parking is 97%. It can be called a typical "hexagonal warrior".

Keep accelerating evolution with technological advantages, and realize safety, comfort and intelligence driven by all data.

As a new brand, Zhiji AutomobileBehind the 2-year-old distance between players in the head is the underlying technical advantage of joint development and two-way empowerment with Momenta.The core competence composed of more efficient architecture, rapidly evolving algorithms and higher utilization of generative data will continue to drive.The accelerated running of IM AD’s intelligent driving evolution.

IM AD is the only dual-intelligent computing platform compatible with Xavier and Orin, and its architecture adaptability is more efficient, the computing power requirement is reduced by 90%, and the running efficiency of the model is greatly improved by 500%.. Based on this, limited computing power can also achieve global visual integration; Only byThe scheme of "single lidar+single Orin chip" can also cover all urban scenes and meet the demand of NOA for high-precision maps.

At the same time,IM AD algorithm has the ability of faster technological evolution. In 2021, OneModel, BEV and Transformer technologies have been implemented, and in 2022, the first car was equipped to achieve mass production, laying the industry-leading technology base. In April 2023, Zhiji Automobile and Momenta released the industry’s first D.L.P artificial intelligence model, which solved the bottleneck problem of cognitive intelligence. The "NOA-to-high-precision map" public beta, which will be launched in September this year, will gradually realize the switching of map technology schemes and realize the uninterrupted assisted driving experience without relying on high-precision maps. On this basis, in 2024, IM AD is expected to enter the application stage of Occupancy occupying the network and realize automatic driving in most scenarios.

　

It is worth noting that, as the peak product of Zhiji automobile intelligence, the third model will be unveiled at Chengdu Auto Show.TomojiLS6, the whole department has NOA ability to go to high-precision maps, and the delivery is equipped with the industry’s first "one-click scene driving" function.on the basis ofIM AD intelligent driving technology solves the high-frequency pain points in the deterministic scene of users’ urban travel.

At present, IM AD is preparing for the technology to go to sea, and has completed the European localization adaptability training, and the planning algorithm has adapted to the local environment and driving habits. In 2024, with the launch of the first global strategic model LS6 of Zhiji Automobile, Zhiji Automobile will share China’s intelligent driving technology with the world, rapidly expand its overseas influence, and let the world see China, and China is the world!