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Cell Stem Cell： dopaminergic progenitor cells derived from human embryonic stem cells in the treatment of Parkinson’s disease

Original biological world

Written by Cong Wang

Edit Wang Duoyu

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Cell therapy is considered to be very suitable for treating Parkinson’s disease (PD) because its pathogenesis is relatively simple and characterized by localized degeneration of dopaminergic neurons in the substantia nigra compacta of the midbrain. In animal experiments and human experiments, transplanting human fetal ventral midbrain tissue or cells has been proved to help restore motor function.

However, these results are often inconsistent, which highlights the need for improved cell therapy programs to ensure that a sufficient number of well-defined midbrain dopaminergic (mDA) neurons are produced and standardized cell preparation and transplantation procedures are adopted.

Recent technological progress has enabled human pluripotent stem cells (hPSC), such as embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC), to efficiently generate mDA neurons, paving the way for establishing transplantation therapy for Parkinson’s disease based on hPSC. Many studies have shown that when transplanted into animal models of Parkinson’s disease, mDA progenitor cells derived from hPSC are well integrated into the host brain and mature into functional mDA neurons, which significantly improves motor function.

Recently, researchers from Yonsei University School of Medicine published a research paper entitled: preclinical and dose-ranging assessment of HESC-derived dopaminergic prognosticators for a clinical trial on Parkinson’s disease [1].

In this study, high-purity midbrain dopaminergic (mDA) progenitor cells were produced on a large scale from clinical human embryonic stem cells (hESC), and the safety and effectiveness of mDA progenitor cells were verified in vitro and in vivo. MDA progenitor cells improved the disease-related behavior of Parkinson’s disease rat model in a dose-dependent manner. Based on these preclinical research results, the research team obtained the approval of the Korean Ministry of Food and Drug Safety for the phase 1/2a clinical trial of cell therapy for Parkinson’s disease, and started the treatment of 12 patients with Parkinson’s disease.

In May, 2020, researchers at Massachusetts General Hospital reported a groundbreaking study in the New England Journal of Medicine (NEJM) [2]. A Parkinson’s patient who received autologous transplantation of mDA progenitor cells from hiPSC showed stable or improved clinical symptoms 24 months after implantation. Now, this method has been further developed, and the mDA progenitor cells derived from hiPSC and hESC began to enter the early clinical trial stage.

The first step in the clinical application of cell transplantation for Parkinson’s disease is to define the characteristics of cell products comprehensively. It is very important to determine whether cells are produced with clinical grade materials under GMP conditions and whether they meet the expected clinical use standards. Subsequently, preclinical research should produce convincing evidence of curative effect through large-scale animal experiments, and systematically examine long-term safety-related issues, such as toxicity, biological distribution and tumorigenicity. In addition, preclinical research needs to determine the optimal cell dose range for transplantation as a reference for human trials. Most importantly, the whole research design must be meticulous and the results must be evaluated in a fair way. This usually requires cooperation with CRO and extensive discussions with regulators.

This paper describes the process and results of a preclinical study aimed at using midbrain dopaminergic (mDA) neurons derived from human embryonic stem cells (hESC) in human clinical trials to treat Parkinson’s disease.

The cell differentiation method used in this study has been optimized for clinical application to ensure that it meets GMP standards. This optimization method can produce mDA progenitor cells with high purity and low temperature preservation on a large scale, while maintaining strict quality control. A year-long large-scale transplantation study by an independent CRO company using immunocompromised rats showed that the transplanted mDA neurons did not cause tumorigenicity, significant toxicity or ectopic integration outside the injection site. In addition, clinical mDA precursor cells showed therapeutic potential and dosage range, and produced therapeutic effects in toxin-induced semi-Parkinson’s rats. These findings provide the necessary information about the appropriate cell dose for human trials.

Specifically, this paper introduces the method of large-scale extraction of high-purity mDA progenitor cells from clinical grade hESC under strict GMP conditions, and also evaluates the toxicity, biological distribution and tumorigenicity of these cells in immunocompromised rats in facilities conforming to good laboratory practices (GLP). Different doses of mDA progenitor cells were transplanted into the semi-Parkinson’s rat model, and it was observed that there was a significant dose-dependent behavior improvement when the minimum effective dose ranged from 5000 to 10000 mDA progenitor cells. These results provide insights for determining the low cell dose (3.15 million cells) in human clinical trials.

Based on these experimental results, the research team obtained the phase 1/2a clinical trial of cell therapy for Parkinson’s disease approved by the Korean Ministry of Food and Drug Safety, and started the clinical trial of treating patients with Parkinson’s disease.

Paper link:

1. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00401-0

2. https://www.nejm.org/doi/10.1056/NEJMoa1915872

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It all depends on it! The entry of durian from Thailand into China has been reduced from 20 days to 3-4 days.

China is an important fruit export market in Thailand. According to the data from the Ministry of Commerce of Thailand, in 2022, China was the largest export market of durian in Thailand, accounting for 96% of its total export volume, with an export value of US$ 3.09 billion. The export target of durian set by Thailand’s Ministry of Commerce this year is 100 billion baht (US$ 1 is about 34 baht). In the first two months alone, the sales volume in China has reached 35,000 tons, 2.4 times higher than the same period last year. Chalengchai, Minister of Agriculture and Cooperatives of Thailand, said: "Thanks to the China market, the planting area of durian and other fruits in Thailand has been expanding, the income of fruit farmers has been increasing, and more and more Thai fruits have entered the China market."

Yunnan Mohan Railway Port Entry Fruit

"With the China market, the fruit business in Thailand is particularly good"

In the evening, Thailand’s Cheuk Chuen suddenly became lively, and traffic jams began at the crossroads. Large container trucks and pickup trucks filled with durians lined up along Highway 3. "In eastern Thailand, the output of durian in Chien Chuen province is the largest, accounting for about 70% of the total. From April to June every year, the evening in Tsim Bamboo House is more lively than during the day. Durian is sensitive to temperature and needs to avoid light as much as possible. The acquisition, sorting, packing and filing of durian all start in the evening and last all night. " Banya, director of the Agriculture Bureau of Tsim Chuk Veng, said.

Eastern Thailand, including the provinces of Tsim Chuen, Luo Yong and Bazhen, is the most important fruit growing area in Thailand. Driving from Bangkok to the southeast, the roadside is green everywhere, and you can see large orchards from time to time. The Nengsong Market in Chien Chu is the largest durian market in Thailand, with thousands of durian stalls, large and small.

"This year’s business is particularly good." The owner, Aigeshan, has been running durian business here for more than 10 years, and has three shops. He said that in the near future, it can sell more than 10 tons a day at most, and both local wholesalers and merchants from China, Viet Nam and Cambodia come to purchase. At present, the wholesale price is 80-100 baht per kilogram. Aigeshan said: "China customers want AB-grade durian with good price and large sales volume, which is the best market for Thai fruit."

At a durian sorting factory in Cheuk Chuen, Thailand, the staff are sorting durians. Xinhua News Agency reporter Wang Teng photo.

Dozens of workers are busy sorting, weighing, packing and loading durian in Tamai County, Jianzhu County. Several pickup trucks are lined up, and the workers in the trucks praise and guess to throw durian. The partners under the trucks skillfully catch it, tap the durian gently with a wooden stick to judge the maturity, and then blow off the dust and debris on the surface with a blowing pipe, and put it into different baskets according to the size. In the peak season, this factory can produce nearly 100 tons of durian in one night.

"’Sister You’ is my mother’s name, and three generations of our family are doing durian business. After I graduated from Bangkok University of Commerce majoring in computer science, I returned to my hometown to engage in durian industry. Now many descendants of fruit farmers choose to return home and use knowledge to develop orchards. With the China market, Thailand’s fruit business is particularly good. " Zhu Tatai, the owner of the factory, said that three months after the acquisition in the east, he would return to his hometown, Chunpeng House in the south, where durian ripened about three months later than in the east. His factory exports thousands of tons of durian to China every year.

At present, there are at least 700 durian sorting factories in Tsim Chuen Prefecture, which are dedicated to the China market. Ben Liang, a fruit grower, said: "China merchants are frank, sincere and have a pleasant cooperation. We are all looking forward to selling more Thai fruits to China. "

"China-Laos Railway special train makes our fruit transportation more convenient"

Since April, durian, mangosteen and other tropical fruits in Southeast Asia have been on the market in large quantities. Every day, a fruit train enters China through China-Laos Railway and is sent to Kunming, Chengdu, Guangzhou and other major cities. Since the beginning of this year, as of April 28th, China-Laos Railway has transported 11,000 tons of mangosteen, durian and other fruits.

In the "Youjie" durian picking and packing factory, generally about 4 kilograms of durians, 5-6 can be packed into a box, each sea container can hold about 1008 boxes, and a factory can hold 5 containers and about 30,000 durians every night. The next day, the truck set out for Lianchabang Port by sea, or sailed to the border of Laos and Vietnam and entered China. At present, Thai fruits are exported to China market by three ways, including 51% by sea, 48% by land and 0.54% by air. The opening of China-Laos Railway has brought new opportunities for Thai fruits to be exported to China.

At a durian sorting factory in Cheuk Chuen, Thailand, the staff are sorting durians. Xinhua News Agency reporter Wang Teng photo.

"In the past, durian was mainly transported to China by road and sea, which was greatly influenced by uncertain factors such as weather, and sometimes the transportation time was as long as 20 days. After the opening of China-Laos Railway, durian will arrive in Kunming in 3-4 days from Thailand, so we can export durian with higher maturity and better taste. The China-Laos Railway special train makes our fruit transportation more convenient. " Aaron Gong, adviser to the Minister of Agriculture and Cooperatives of Thailand, said.

Yang Tai Group has been engaged in Thailand’s fruit import and export trade for more than 20 years. The company exports tens of thousands of tons of fruit to China every year, most of which are sold to wholesale markets in Beijing and Guangzhou. Yang Ju, president of the company, said: "China-Laos Railway has short transportation time and high stability. Railway transportation not only ensures the quality of durian but also reduces operating costs."

According to reports, durian can be transported from Thailand to Chongqing in 4-5 days and Guangzhou in 5-6 days after being transported by China-Laos Railway. "China-Laos Railway’s transportation and customs clearance are very fast. The first batch of fruits took only five days from the Thai factory to the Guangdong, China market." The relevant person in charge of Thailand PAS Company, which is engaged in the transportation and export of durian and mangosteen to China, said that the opening of durian train will open up a new road for the export of durian in Thailand, and this year’s goal is to export 700-1,000 containers of various Thai products through this route.

"The income of Thai fruit farmers, buyers and exporters continues to increase"

From time to time, reporters saw the giant billboard of "Building the Fruit Capital of the World" on the streets of Tsim Chuen House. In 2018, Thailand approved the strategic plan for fruit development and set the goal of building Thailand into a major tropical fruit trading country in the world.

In recent years, the Thai government has strengthened the management and support of the fruit industry, including inspecting plantations, helping enterprises and farmers distribute fruits, and improving the mobility of exporters. Thailand’s Ministry of Commerce and the Ministry of Agriculture and Cooperatives often organize farmers, purchasers, exporters, logistics and transportation service providers, foreign business representatives and commercial bureaus in fruit-rich areas to discuss how to strengthen fruit management, and formulate a number of measures, including speeding up inspection and certification, helping enterprises or farmers to export fruits as agents, and helping exporters solve working capital.

On April 19th, Thai durian arrived in Kunming through China-Laos Railway.

In this year’s fruit sales management, Thailand has set up a working group composed of government departments and the private sector to promote Thailand’s fruit export, which is responsible for supervising the production and marketing situation and coordinating and solving the fruit export problems. The Director of the Department of Agriculture of the Ministry of Agriculture and Cooperatives of Thailand, Mr. Sapipa, said that the Department of Agriculture requires all departments to follow all steps from the source to the downstream. The source is the orchard, the middle reaches is the packaging factory, and the downstream is the inspection and quarantine gates of various plants. All departments must cooperate with each other to jointly maintain and improve the quality and standards of durian and other fruits in Thailand.

Banya said: "Quality is the most critical. In all aspects of planting, cultivation, picking and transportation, the government management department and the private sector cooperate to strictly control all fruit orchards to ensure the quality of Thai fruits."

The Ministry of Commerce of Thailand predicts that 70% of Thailand’s fruit production will be exported to the international market this year, with China as the largest export destination. Yin Mengshi, the government of Chien Chuen, said: "The strong demand in China market has promoted the development of durian industry in Thailand, and the income of Thai fruit farmers, buyers and exporters has continued to increase."

Zhu Lin, Deputy Prime Minister and Minister of Commerce of Thailand, expressed the hope to further increase fruit exports to the China market this year. "China is an important trading partner of Thailand, especially in the fields of agricultural products and fruits. With the support of China, Thai fruits can go to the world faster and help build Thailand into a world tropical fruit trading country. "

Wonderful in the past

Original title: "It all depends on it! The entry of durian from Thailand into China has been reduced from 20 days to 3-4 days.

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Lee Wan’s first step to return to the big screen after joining the ＂Yanping Naval Battle＂

　 　 Lee Wan is the younger brother of South Korean actress Jin Taixi. In 2003, he performed the same TV series "The Stairs of Heaven" with Jin Taixi, playing Shen Xianjun’s boyhood, and successfully made his debut in the entertainment industry. In 2005, he cooperated with the mythical JUNJIN to "Go to the seaside". In 2006, he participated in a Japanese film, and the film was also shortlisted for the Tokyo Film Festival. Since 2010, he has served in the Korean National Defense Propaganda Institute and retired in 2012. In 2013, he starred in "Because I haven’t broken up yet" and returned to the TV screen. The Battle of Yeonpyeong will also be his first work to return to the big screen after his retirement.

Skyworth EV6 new model debut! Price 162,800 yuan, battery life 410 kilometers

2024 410 travel version officially launched, priced at 162,800 yuan, using the starry sky gray appearance color scheme, MIIT data shows that its pure electric battery life can reach 410 kilometers. Skyworth EV6 is a medium-sized SUV, the new model launched this time retains the old model design, the front face design adopts a closed air intake grille, matched with L-shaped metallic decorative strips, the body size is 4720 mm long, 1908 mm wide, 1696 mm high, and the wheelbase is 2800 mm.

In terms of configuration, the 2024 Skyworth EV6 410 Travel Edition provides a variety of practical functions, including automatic parking, steep descent, front/rear parking radar, four-door window one-click lift, keyless start, automatic air conditioning, rear air conditioning out of trend, imitation leather seats, etc.

In terms of power system, the car is equipped with a front single motor, with a maximum power of 150 kW, a maximum torque of 320 Nm, a 51.92 kWh battery pack, and a MIIT pure electric battery life of 410 kilometers. The launch of this new model will further enrich Skyworth’s EV6 product line and provide consumers with more choices.

Media： The controversy of Meicheng mooncakes is not over, and there is also a problem with the mooncakes brought by ＂Walking with Hui＂？

Just as "Crazy Little Brother Yang" was making a lot of noise because of the suspected false propaganda of selling "Hong Kong Meicheng Mooncakes" in the live stream, the controversy about the moon cakes in the live stream continued to ferment. On September 18, some netizens broke the news to reporters that the Macau Portuguese Mooncakes sold in the live stream of "Walking with Hui" were also suspected of having quality problems.

According to the reporter’s understanding, the previously recommended one in the live stream of "Walking with Hui" is called "Macau Portuguese Kee Liuxin Cream Mooncake" sold in the Douyin flagship store of "Portuguese Kee Food Flagship Store", priced at 108 yuan per box. The product packaging shows that the producer of this mooncake is "Macau Portuguese Kee Food Co., Ltd.", and the manufacturer is "Zhuhai Portuguese Kee Food Co., Ltd.", and the origin is in Zhuhai, Guangdong.

However, it is worth noting that according to data from platforms such as Qichacha and Qixinbao, "Macau Portuguese Kee Foods Co., Ltd. is registered in Hong Kong. Although its status is" still registered ", it has not only been" registered revoked ", but also applied for" dormant activity "status on May 31, 2024. According to Article 327A of the Hong Kong Companies Ordinance, a company can decide to conduct a dormant activity through a special resolution, but one of the conditions for the dormant activity is that" the company cannot continue to operate or temporarily suspend operations. "

Through relevant information, it can be seen that the producer of the "Macau Portuguese Keeping Heart Milk Mooncake" recommended by the live stream of "Walking with Hui" in September this year has stopped operating in May this year, which has also caused many consumers to worry about the quality assurance of this product.

According to the reporter’s understanding, "Macau Portuguese Kee Liuxin Milk Yellow Mooncake" products are not only sold through the live stream of "Walking with Hui", but also sold in multiple live stream rooms such as "Make a Friend".

Lynk & Co 08 hot promotion in Tianjin, the minimum is only 178,800! Quantity is limited

In [Easy Car Tianjin Local Auto Market Discount Promotion Channel], we have sorted out the ongoing
Promotions. As a model that has attracted much attention, the price reduction of the Lynk & Co 08 is still very amazing. The highest discount can even reach 17,000. The minimum starting price is only 178,800. You can get a larger discount by clicking the "Inquire" button in the quotation form. If you are looking for a practical and affordable model, you may wish to find out about the discounts of the Lynk & Co 08.

First of all, from the appearance point of view, the front of the Lynk & Co 08 adopts a very fashionable and simple design, which looks more exquisite. The headlights are dynamic, and many interesting details can be seen from the inside. The car is equipped with LED daytime running lights, headlight height adjustment, automatic opening and closing, adaptive far and near light, delayed closing, etc. Come to the side of the car, the body size of the car is 4820MM*1915MM*1685MM, the car adopts deep and elegant lines, the side looks very soft, and with large-sized thick-walled tires, it looks sporty. In terms of the rear, the rear of the car and the front face echo each other, the style of the taillights is relatively calm, and the overall shape is still very durable.

Sitting in the car, the interior design of Lynk & Co 08 has taken a comfortable route, which is easy to impress the hearts of young consumers. The steering wheel shape of the car is eye-catching, and it is made of genuine leather material, which gives a good grip experience. Let’s take a look at the central control, with a 15.4-inch central control screen, which makes the interior style impressive and looks stylish. Finally, look at the dashboard and seats, which highlights the trendy temperament. The car uses leather seats, which are well-wrapped and comfortable.

As a brand-new luxury mid-sized SUV, the exterior design of the Lynk & Co 08 is very eye-catching. Its unique styling style and detail handling all show the designers’ superb skills, making people recognize it as a Lynk & Co brand product at a glance. In terms of power, the Lynk & Co 08 is equipped with a strong engine that can provide sufficient power output, allowing drivers to enjoy unparalleled driving pleasure. In addition, the overall space performance of the Lynk & Co 08 is also very good, whether it is the front or the back, you can get a spacious and comfortable ride experience. Overall, the Lynk & Co 08 is an excellent model with beautiful appearance, full power and excellent space performance, which deserves consumers’ attention and choice.

Blue Power E5 in Qujing area is being discounted! 40,100, limited-time special offer

[Autohome Qujing Discount Promotion Channel] Good news! At present, the models that have attracted much attention are launching an unprecedented promotion in Qujing area. This promotion is designed to give back to consumers and provide real car purchase benefits for car buyers. It is reported that the maximum discount amount has reached an astonishing 40,100 yuan, and the minimum starting price has been reduced to an attractive 99,800 yuan. For friends who have car purchase plans, this is a car purchase opportunity not to be missed. Want to know more specific discount details and get a higher car purchase discount? Please click the "Check Car Price" button in the quotation form now, and hurry up and act!

曲靖地区蓝电E5正在优惠！优惠4.01万，限时特惠

曲靖地区蓝电E5正在优惠！优惠4.01万，限时特惠

With its exquisite body design, the Blue Electric E5 has a length, width and height of 4760mm x 1865mm x 1710mm, and a wheelbase of 2785mm, providing passengers with a spacious interior space. The side lines of the body are smooth, showing elegant proportions and dynamics. The tire specifications are unified as 225/55 R18, and the front and rear wheelbases are 1585mm and 1580mm respectively. This configuration not only enhances the stability of the vehicle, but also ensures the comfort during driving. Overall, the Blue Electric E5 shows a good balance in appearance and practicality.

曲靖地区蓝电E5正在优惠！优惠4.01万，限时特惠

The interior design of the Blue Electric E5 is exquisite and practical, showing the style of technology and comfort coexisting. It is equipped with a 12.3-inch central control screen with clear display and convenient operation. It integrates functions such as multimedia system, navigation, telephone, air conditioning and sunroof, providing comprehensive information support for the driver. The steering wheel is made of leather material, providing a good grip, and supports manual up and down adjustment to ensure driver comfort. In the car, there are 1 USB/Type-C interfaces in the front and 1 in the back, which is convenient for passengers to charge and data transmission. The seats are made of imitation leather, and the main and passenger seats support front and rear, backrest and high and low multi-directional adjustment to adapt to the needs of different drivers. The second row of seats is also equipped with backrest adjustment function, and the space layout is flexible. The entire interior design not only focuses on practicality, but also on details to create an elegant and comfortable interior atmosphere.

曲靖地区蓝电E5正在优惠！优惠4.01万，限时特惠

The Blue Electric E5 is equipped with a 1.5L 110 horsepower L4 engine with a maximum power of 81 kilowatts, providing a stable power output for the vehicle. Matched with the E-CVT continuously variable transmission, this high-efficiency transmission design ensures a smooth driving experience and good fuel economy. The torque output is 135 Nm, which can meet the various needs of daily driving.

In general, the Autohome owner is full of praise for the exterior design of the Blue Electric E5, believing that its atmosphere is calm, the through-type LED light strip on the front face is impressive, and the smoothness of the body line further enhances the overall look and feel. Especially the 23-inch large tires make the momentum of the vehicle even more extraordinary. This design undoubtedly satisfies his pursuit of high-end and individuality. I believe that in the future driving, this Blue Electric E5 will become his proud driving partner.

2025 Ford Mondeo launched, priced at 14.98.

The 2025 Ford Mondeo was officially launched today (September 26). The new model launched a total of 9 models, priced at 14.98-22 9,800 yuan. As a facelift, the new car will maintain the design of the old model as a whole, but will add new car colors and launch E-hybrid models.

In terms of benefits, the car purchase enjoys 0 down payment and 0 interest rate, and the maximum car purchase gift is 26,888 yuan, including 1 yuan for a limited time plus 2,000 yuan cash blessing cash gift, 5,700 yuan for a limited time car purchase subsidy car purchase travel gift, up to 10,000 yuan Intimate replacement gift, 3 free basic maintenance worry-free maintenance gifts in 3 years, up to 8,200 yuan financial subsidy and renewal financial gift.

The exterior part basically maintains the fuel version design, the front air intake grille uses the "3D parametric scale net" shape, but the breathing undulation function has been cancelled. In addition, the headlight group is a split design, the upper part is a long and narrow LED daytime running light, the middle is an LED daytime running light strip connected, and the lower far and near light group is integrated with the surrounding, forming a double-sided heat dissipation opening shape, so it is also very recognizable.

The side of the body maintains a strong body line, and the double waist line with high window line, coupled with the floating roof, also creates a thicker visual effect. In addition, the two-tone body design, chrome trim strips along the roof, and hidden door handles also enhance the visual impact of the body. There are also slightly prominent front and rear fenders, and wheels equipped with low wind resistance styling, and the tire size is 235/45 R19.

The tail of the car body is still a short tail design, the thick tail line presents a layered effect, and the internal blackening of the rear light group also brings a stronger sense of movement. Although the hidden exhaust is used, the shape of the exhaust port is still outlined through chrome decorative strips, and there is a small diffuser shape under the bumper.

The interior part, the Mondeo hybrid version and the fuel version are basically the same, the interior part is still minimalist style, the central control of the large through-type screen width of 1.1 meters, specifications of 27 inches, 4032 * 756 resolution, can achieve split-screen operation. In terms of configuration, the Ford Co-Pilot360 intelligent driving assistance system equipped with up to 17 functions has adaptive cruise and automatic parking and other driving auxiliary features.

In terms of power, the Mondeo hybrid version will be equipped with a hybrid system composed of a 1.5T four-cylinder turbocharged gasoline engine and an electric motor, of which the gasoline engine has a maximum power of 138kW. The fuel version will continue to be equipped with a 1.5T turbocharged engine and a 2.0T turbocharged engine, with a maximum power of 140kW and 187kW respectively, and a maximum torque of 258 Nm and 393 Nm respectively. The transmission is matched with an 8AT gearbox.

[The picture in this article is from the Internet]

Nearly half of the demand has not responded, and the new policy has hit Beijing.

　　CCTV News:From the 21st, Beijing will officially implement the "Detailed Rules for the Implementation of Online Car-hailing Service Management". The "Detailed Rules" clearly put forward the provisions of "Beijing-registered personnel and Beijing-registered vehicles", requiring individuals and vehicles connected to the online car-hailing platform to be reviewed and have relevant qualifications before they can operate on the road.

　

　　Beijing’s new car-hailing policy is implemented　

　　On December 21, 2016, the "Implementation Opinions of the General Office of the Beijing Municipal People’s Government on Deepening Reform and Promoting the Healthy Development of the Taxi Industry" and the "Implementation Rules for the Management of Online Booking Taxi Business Services in Beijing" were officially released. Now, after a five-month transition period, the implementation of the new policy on online car-hailing in Beijing has been officially implemented.

　　The requirements for vehicles in the Detailed Rules are as follows: 5-seat sedan passenger cars with a displacement of not less than 1.8L; vehicle wheelbase of not less than 2650 mm; 7-seat passenger cars with a displacement of not less than 2.0 liters and a wheelbase of not less than 3000 mm, have not reached the legal retirement age, government agencies, enterprises, institutions and social organizations are not allowed to engage in online car-hailing operations, reasonably determine the online car-hailing metering method, and must not have improper price behavior.

　　At present, the five online car-hailing platforms operating online car-hailing in Beijing have all obtained qualifications. Didi and Shenzhou are arranging for drivers to obtain qualification certificates; Shouqi car-hailing announced the opening of APIs for compliance personnel and vehicles to join.

　　"One size fits all" requires drivers to hold a license?

　　This year, nearly 20,000 people in Beijing have applied to take the test, and more than 1,200 drivers have completed the test. "Beijing’s online taxi driver test is divided into two types, one is the taxi driver transfer test, and the other is the social driver test." On January 26, Beijing’s online car-hailing drivers took the first batch of tests, and a total of 73 drivers of Shouqi Car-hailing passed the test successfully. Master Meng Tao of Shouqi Car-hailing received Beijing’s first online car-hailing driver qualification certificate, certificate number 1100000001.

　　Social drivers can log in to the official website of the Municipal Transportation Commission Transportation Bureau to inquire about the exam syllabus, exam materials and review materials.

　　A relevant person from the Traffic Law Enforcement Corps of the Beijing Municipal Transportation Commission said that considering the different order in which the platform obtains the operation license and the degree to which the driver conducts the test, after the transition period, the law enforcement officers will not require the driver to hold the license "one size fits all".

　　Citizens report that it is difficult to get a car

　　On the first day of the implementation of the new policy of online car-hailing in Beijing, how did the citizens of Beijing react? The reporter randomly interviewed the citizens of Beijing, and they said that it has become difficult to call a car. In the past, it may have arrived in one or two minutes, but now it may take five or six minutes to ten minutes if it is slow. Especially in the morning, I am in a hurry to go to work and sometimes I can’t get a car.

　　The detailed rules for the management of online car-hailing in various places are gradually being implemented

　　Beijing has officially implemented the new policy of "online car-hailing", and in cities such as Taiyuan in Shanxi and Foshan in Guangdong, the new policy of online car-hailing will also be officially implemented from June 1. From the money-burning war a few years ago to today’s standardized operation, what is people’s attitude towards the implementation of the new policy of online car-hailing?

　　The reporter found in the investigation that with the gradual implementation of the new policy of online car-hailing, many passengers began to encounter the problem of difficulty in taking a taxi. The reason behind this is the new policy of online car-hailing in various places, which restricts drivers and vehicles.

　　According to statistics, in the current "detailed rules for online car-hailing" in 73 cities or regions across the country, more than 80% require drivers to have local household registration or residence permits; more than 90% require online car-hailing cars to have local license plates or register locally; and more than 40 cities have even put forward specific standards for the wheelbase of online car-hailing cars.

　　[Difficult to take a taxi]"Locals local car" demand or nearly half unresponsive

　　The data provided by the Didi platform shows that in March this year, the success rate of using express taxis in Beijing was the highest from 10 am to 5 pm, at 83.2%, which is equivalent to one out of every six appointments without a driver taking orders. However, during the night rush from 9 pm to 11 pm, the average success rate was only 54.1%, and almost half of the orders went unanswered.

　　[Taxi is expensive]There is a premium during peak periods, which is not cheaper than ordinary rentals.

　　Another phenomenon brought about by the difficulty of hailing a taxi is the increase in prices. At around 9:30 pm, the reporter tried to book an online ride-hailing near Financial Street in Beijing’s West Second Ring Road. Since this is the peak ride-hailing period, the fare premium is 1.3 times.

　　A few years ago, the large-scale red envelope subsidy has basically disappeared. The price of online car-hailing is no cheaper than that of ordinary taxis, while some high-end special cars are more expensive.

　　[Taxi safety]Safety has been greatly improved, and passengers can book a car with greater confidence

　　With the implementation of the new policy, online car-hailing seems to be more difficult than before, with higher prices, but there are also advantages. Many passengers believe that the new policy has greatly improved the safety of online car-hailing, which is more reassuring.

Brush the screen! The 63-year-old chairman of China’s largest gold mine married his 38-year-old wife. The company has a market value of 150 billion yuan. Bride： Believe in love!

Source: China Gold Online Network
A shares closed in September: the Shanghai Composite Index fell by more than 5% in five consecutive Yin San stock indexes.
Is it love or money behind the marriage with a difference of 26 years?
On October 7th, the wedding of Chen Jinghe, chairman of Zijin Mining, was brushed on Weibo Hot Search.
Image source: Sina Weibo
The bride said at the wedding that true love can cross and break through the boundaries of age. The groom is the owner of the largest gold mine in China, and the market value of listed companies exceeds 150 billion. The bride, Ms. Qian Bing, is an economist and M&A dealer.
The video circulating on the Internet shows that at the wedding, the bride Qian Bing teased that when she first met Chen Jinghe, the mining expert might have found that the girl in front of her was a high-grade gold mine.
The wedding is hotly debated.
It is said that in China, gold has Chen Jinghe, copper has Wang Wenyin and aluminum has Zhang Shiping.
According to the data, 63-year-old Chen Jinghe graduated from Fuzhou University with a master’s degree in geology, a professor-level senior engineer, enjoying special allowance from the State Council, a deputy to the Tenth People’s Congress of Fujian Province, and a vice president of the China Gold Association. From 1986 to 1992, he worked in Minxi Geological Brigade, was the main discoverer and exploration organizer of Zijinshan Copper Mine, and served as the chairman of Zijin Mining since 2000.
While netizens are curious about what kind of beautiful woman the chairman of this listed company with a market value of over 150 billion yuan married, the 25-year-old age difference between 63-year-old Chen Jinghe and 38-year-old newlywed wife also triggered a heated discussion among netizens. Some netizens said that they "don’t believe in love", and some netizens thought that "a perfect match is a blessing".
Net biography, the bride’s name is "Qian Bing", an American MBA, who has served as the vice president of the channel department of a famous financial company for many years, and is an economist and M&A trader. In this regard, some netizens ridiculed that this marriage is the most successful merger and acquisition made by Ms. Qian.
Image source: Netease News
Many netizens have begun to express "believe in love"
It is understood that Chen Jinghe was not married for the first time. His first wife Lai Jinlian died of illness in January 2013, and Chen Jinghe sent a special message to mourn his beloved wife.
Wind data shows that Zijin Mining has a total market value of 156.1 billion yuan and a total share capital of 25.4 billion shares. The latest share price of A shares is 6.15 yuan, and the share price of Hong Kong stocks is 5.16 Hong Kong dollars. The actual controller of Zijin Mining is Minxi Xinghang State-owned Assets Investment Management Co., Ltd.
According to the 2019 annual report, as of the end of last year, Chen Jinghe held 127 million shares, which was not among the top ten shareholders.
Image source: the company’s 2019 annual report
According to the semi-annual report of Zijin Mining in 2020, on July 27th, 2020, Chen Jinghe transferred 51 million A shares of the company to his son due to the arrangement of family property distribution. According to the latest stock price calculation, these shares are worth 314 million yuan.
Image source: 2020 semi-annual report
As of the reporting period, Chen Jinghe still holds 76.05 million shares of the company (including 15 million H shares). According to the latest stock price calculation, its market value of A shares is 375 million yuan, and the market value of Hong Kong shares is 77.4 million Hong Kong dollars.
Flying out of overseas "black swan"
In April this year, Zijin Mining announced that the company’s Bogla gold mine project in Papua New Guinea (hereinafter referred to as "Papua New Guinea") did not obtain the application for extension of the special mining rights of the Papua New Guinea government.
The data shows that from 2017 to 2019, the mineral gold of Zijin Mining was 37.48 tons, 36.5 tons and 40.83 tons respectively. In 2019, the company got 8.83 tons of equity output from Bogla Gold Mine, which was the largest source of mineral gold, accounting for about 21% of the company’s total mineral gold in that year. The company’s second and third largest gold mines did not exceed 6 tons. Zijin Mining said that the suspension of production of Pogra gold mine will have a greater impact on the company’s gold production. Affected by this, Zijin Mining’s share price plummeted by more than 9% the day after the announcement, and fell by nearly 10 billion yuan in just one day.
According to the latest news of mining journal, on September 25th, the Supreme Court of Papua New Guinea rejected the application for the renewal of the mining right of Bogla Gold Mine. The Supreme Court of Papua New Guinea also ruled that the gold mine will be operated by the Papua New Guinea state-owned enterprise Kumur Mining Holdings Co., Ltd.
Meanwhile, on September 30th, PNG Prime Minister James Marape issued a statement: "I urge barrick companies to be humble and abide by the rule of law." According to the statement, in the mining development contract signed by barrick and PNG Mineral Resources Administration in 1989, there was a clause that reserved the government’s right to Pogra Gold Mine, namely, "Pogra Gold Mine became a national asset on the date when the mining right expired, and the state did not bear any expenses or compensation."
Although the "black swan incident" was exposed, the shares of Zijin Mining A shares and Hong Kong stocks have been on the rise since March. Among them, in just 113 trading days from March 19 to September 1, the cumulative increase of A-share price was as high as 119.28%, and then it fell back.
Source: Wind
As for the decline in output that may be caused by the extension of the application for renewal of mineral rights in Bogla Gold Mine, Chuancai Securities believes that Zijin Mining’s acquisition of Buritika Gold Mine and Guiana Gold Field will increase the production capacity of 13 tons of mineral gold, which can effectively make up for the decline in output that may be caused by the extension of mineral rights in Bogla Gold Mine. In the future, the company’s mineral gold output will grow steadily and remain above 40 tons.
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