Cell Stem Cell: dopaminergic progenitor cells derived from human embryonic stem cells in the treatment of Parkinson’s disease

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Written by Cong Wang

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Cell therapy is considered to be very suitable for treating Parkinson’s disease (PD) because its pathogenesis is relatively simple and characterized by localized degeneration of dopaminergic neurons in the substantia nigra compacta of the midbrain. In animal experiments and human experiments, transplanting human fetal ventral midbrain tissue or cells has been proved to help restore motor function.

However, these results are often inconsistent, which highlights the need for improved cell therapy programs to ensure that a sufficient number of well-defined midbrain dopaminergic (mDA) neurons are produced and standardized cell preparation and transplantation procedures are adopted.

Recent technological progress has enabled human pluripotent stem cells (hPSC), such as embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC), to efficiently generate mDA neurons, paving the way for establishing transplantation therapy for Parkinson’s disease based on hPSC. Many studies have shown that when transplanted into animal models of Parkinson’s disease, mDA progenitor cells derived from hPSC are well integrated into the host brain and mature into functional mDA neurons, which significantly improves motor function.

Recently, researchers from Yonsei University School of Medicine published a research paper entitled: preclinical and dose-ranging assessment of HESC-derived dopaminergic prognosticators for a clinical trial on Parkinson’s disease [1].

In this study, high-purity midbrain dopaminergic (mDA) progenitor cells were produced on a large scale from clinical human embryonic stem cells (hESC), and the safety and effectiveness of mDA progenitor cells were verified in vitro and in vivo. MDA progenitor cells improved the disease-related behavior of Parkinson’s disease rat model in a dose-dependent manner. Based on these preclinical research results, the research team obtained the approval of the Korean Ministry of Food and Drug Safety for the phase 1/2a clinical trial of cell therapy for Parkinson’s disease, and started the treatment of 12 patients with Parkinson’s disease.

In May, 2020, researchers at Massachusetts General Hospital reported a groundbreaking study in the New England Journal of Medicine (NEJM) [2]. A Parkinson’s patient who received autologous transplantation of mDA progenitor cells from hiPSC showed stable or improved clinical symptoms 24 months after implantation. Now, this method has been further developed, and the mDA progenitor cells derived from hiPSC and hESC began to enter the early clinical trial stage.

The first step in the clinical application of cell transplantation for Parkinson’s disease is to define the characteristics of cell products comprehensively. It is very important to determine whether cells are produced with clinical grade materials under GMP conditions and whether they meet the expected clinical use standards. Subsequently, preclinical research should produce convincing evidence of curative effect through large-scale animal experiments, and systematically examine long-term safety-related issues, such as toxicity, biological distribution and tumorigenicity. In addition, preclinical research needs to determine the optimal cell dose range for transplantation as a reference for human trials. Most importantly, the whole research design must be meticulous and the results must be evaluated in a fair way. This usually requires cooperation with CRO and extensive discussions with regulators.

This paper describes the process and results of a preclinical study aimed at using midbrain dopaminergic (mDA) neurons derived from human embryonic stem cells (hESC) in human clinical trials to treat Parkinson’s disease.

The cell differentiation method used in this study has been optimized for clinical application to ensure that it meets GMP standards. This optimization method can produce mDA progenitor cells with high purity and low temperature preservation on a large scale, while maintaining strict quality control. A year-long large-scale transplantation study by an independent CRO company using immunocompromised rats showed that the transplanted mDA neurons did not cause tumorigenicity, significant toxicity or ectopic integration outside the injection site. In addition, clinical mDA precursor cells showed therapeutic potential and dosage range, and produced therapeutic effects in toxin-induced semi-Parkinson’s rats. These findings provide the necessary information about the appropriate cell dose for human trials.

Specifically, this paper introduces the method of large-scale extraction of high-purity mDA progenitor cells from clinical grade hESC under strict GMP conditions, and also evaluates the toxicity, biological distribution and tumorigenicity of these cells in immunocompromised rats in facilities conforming to good laboratory practices (GLP). Different doses of mDA progenitor cells were transplanted into the semi-Parkinson’s rat model, and it was observed that there was a significant dose-dependent behavior improvement when the minimum effective dose ranged from 5000 to 10000 mDA progenitor cells. These results provide insights for determining the low cell dose (3.15 million cells) in human clinical trials.

Based on these experimental results, the research team obtained the phase 1/2a clinical trial of cell therapy for Parkinson’s disease approved by the Korean Ministry of Food and Drug Safety, and started the clinical trial of treating patients with Parkinson’s disease.

Paper link:

1. https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00401-0

2. https://www.nejm.org/doi/10.1056/NEJMoa1915872

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Hongqi Guoya’s latest offer

Hongqi Guoya’s latest offerBetween 1.08 million yuan and 2.08 million yuan., the specific price range is as follows:

The price of the 3.0T model is expected to be between 1.1 million yuan and 1.2 million yuan, of which the entry-level model is priced at about1.08 million yuan, the high-end version is priced at about1.18 million yuan. The price of the 4.0T model is between 1.3 million yuan and 1.46 million yuan, of which the five-seat version is priced at about1.3 million yuan, the four-seat version is priced at about1.46 million yuan.

Hongqi Guoya’s market positioning is higher than that of Mercedes-Benz S-Class sedan, and it may even compete with luxury brands such as Bentley or Rolls-Royce, showing its high-end market positioning.

Qingdao Blue Electric E5 price reduction news, special offer 99,800! Limited time special offer

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青岛蓝电E5降价消息,特价9.98万!限时特惠

The exterior design of the blue electric car series E5 is very modern and technological. Its front face adopts a unique air intake grille layout with smooth lines, which not only enhances the visual impact of the vehicle, but also optimizes the aerodynamic performance. The overall style is exquisite and dynamic, integrating future design concepts, showing the persistent pursuit of detail and aesthetics of the blue electric E5.

青岛蓝电E5降价消息,特价9.98万!限时特惠

The Blue Electric E5 presents a modern feel with its exquisite body design and smooth side lines. The body size is 4760mm x 1865mm x 1710mm, and the wheelbase reaches 2785mm, which makes the interior space layout of the vehicle more reasonable. The front and rear wheel tracks are 1585mm and 1580mm respectively, ensuring the stability and balance of the vehicle. The tire size is 225/55 R18. Whether it is the front or rear wheels, the same specifications are selected, and the elegant wheel rim style is combined to create the unique appearance aesthetic of the Blue Electric E5.

青岛蓝电E5降价消息,特价9.98万!限时特惠

The interior design of the Blue Electric E5 is dominated by simplicity and technology, showing a refined and practical style. The steering wheel is made of leather material, which is delicate to the touch and supports manual up and down adjustment to adapt to the driver’s needs. The center console is equipped with a large 12.3-inch central control screen, which integrates multimedia systems, navigation, telephone, air conditioning and sunroof control, providing drivers with comprehensive information and convenient operation. The seat part is made of imitation leather material, which makes it comfortable to sit and wear-resistant. The main and passenger seats support front and rear adjustment, backrest adjustment and high and low adjustment to meet the individual needs of different drivers and passengers. The rear seats provide backrest adjustment function and support proportional reclining, which makes space utilization flexible. The overall interior design emphasizes both functionality and detail, creating a warm and efficient driving environment.

青岛蓝电E5降价消息,特价9.98万!限时特惠

The car series Blue Electric E5 is equipped with a 1.5L displacement L4 engine, which has a maximum power of 81 kilowatts and a maximum torque of 135 Nm. It is matched with an advanced E-CVT continuously variable transmission, providing excellent performance and fuel efficiency for the vehicle.

Summarizing the evaluation of Autohome owners, the Blue Electric E5 won his admiration for its atmospheric and fashionable appearance and powerful lines, especially the domineering exposed air intake grille, which undoubtedly added a unique charm to this model. This is not only a bright spot in appearance, but also a manifestation of its inherent strength, making people look forward to the driving experience of the Blue Electric E5.

Pre-sale 170,000, the new Hongqi H5 will be available on July 26

[Autohome News] Recently, we officially learned that the new Hongqi H5 will be officially launched on July 26. The new car adopts the Hongqi family-style design language, the shape is more domineering, and the power will be equipped with HEV hybrid system. Previously, the new car has been pre-sold, and the pre-sale price starts from 170,000 yuan.

FAW Hongqi, Hongqi H5 2023 2.0T Automatic Zhilian Banner Chang Edition

FAW Hongqi, Hongqi H5 2023 2.0T Automatic Zhilian Banner Chang Edition

In terms of appearance, the new Hongqi H5 features a large-size front air intake grille with a straight waterfall-style center grid design, resulting in a more harmonious overall shape. The light groups on both sides are split-type, and the LED daytime running lights above are connected to the front grille to form an integrated structure. The far and near light groups below are integrated with the front surround, and the overall details are matched to make the new car full of aura.

FAW Hongqi, Hongqi H5 2023 2.0T Automatic Zhilian Banner Chang Edition

FAW Hongqi, Hongqi H5 2023 2.0T Automatic Zhilian Banner Chang Edition

On the side of the body, the new car maintains the traditional sedan style and adopts a double waist line design. The front waist line is slightly lower than the back waist line. The two meet in the middle of the body, and the concave, convex and undulating shape makes the new car more layered. In addition, the new car is also equipped with dense-spoke 18-inch wheels, which further enhances the vehicle’s sense of style.

FAW Hongqi, Hongqi H5 2023 2.0T Automatic Zhilian Banner Chang Edition

In the rear part of the car, the new car uses a through-type tail light group. The main body of the tail lights on both sides adopts a special-shaped design, which is very recognizable. The rear surround is also matched with chrome-plated decorative strips and a bilateral exhaust layout, which further enhances the luxury texture of the whole car. In terms of size, the length, width and height of the new car are 4988/1875/1470mm respectively, and the wheelbase is 2920mm.

FAW Hongqi, Hongqi H5 2023 2.0T Automatic Zhilian Banner Chang Edition

In the interior part, the new car is equipped with a full LCD instrument panel and a three-spoke multi-function steering wheel. The central control multimedia display adopts a vertically embedded layout, and the electronic shift mechanism below makes the interior of the new car full of technological atmosphere.

FAW Hongqi, Hongqi H5 2023 2.0T Automatic Zhilian Banner Chang Edition

FAW Hongqi, Hongqi H5 2023 2.0T Automatic Zhilian Banner Chang Edition

In terms of power, the new car will be available in three power versions: 1.5T, 2.0T and 1.5T HEV, with a maximum power of 169 horsepower, 224 horsepower and 169 horsepower respectively. In addition, a 1.8T turbocharged engine will be provided, with a maximum power of 197 horsepower. (Compiler/Zhang Xiaodan)

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The front face of the Toyota Asian Dragon is shaped by its unique design language, which shows a refined and dynamic style. The air intake grille features a bold and tension-filled shape and chrome-plated material, which adds luxury and identity to the vehicle. The overall appearance is smooth, blending power and elegance. Whether it is the side profile or the rear design, it shows exquisite craftsmanship and dynamic aesthetics that make it unforgettable at a glance.

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The side lines of the Asian Dragon are smooth and dynamic, and the body size reaches 4990mm*1850mm*1450mm, and the wheelbase reaches 2870mm, creating a solid and spacious interior space. The front and rear track are 1595mm and 1605mm respectively, ensuring good driving stability. The tire size is 215/55 R17, and the delicate wheel design not only improves the overall visual effect, but also takes into account the comfort and handling performance.

南宁亚洲龙降价消息,特价14.38万!错过就没有

Asian Dragon’s interior design pays attention to detail and comfort, and adopts a refined style to create an elegant space atmosphere. The steering wheel is made of plastic material, although it is not a high-grade material, it feels stable and supports manual up and down + front and rear adjustment to meet the driver’s personalized needs. The center console is equipped with a 10.25-inch high definition touch screen, which is easy to operate and has a clear display, providing a rich infotainment experience for drivers and passengers. The seats are made of fabric, which makes it comfortable to sit. The main and passenger seats support front and rear adjustment, backrest adjustment and high and low adjustment to ensure the comfort of long-distance driving. At the same time, the car is equipped with USB/Type-C ports, with 3 in the front row and 2 in the back row, which provides convenience for charging passengers’ electronic devices. The overall interior design strikes a balance between practicality and beauty, creating a warm and technological driving environment for users.

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For the Asian Dragon series, the 2.0L engine with 173 horsepower output and a maximum torque of 206 N · m is equipped with an L4 design to ensure smooth operation of the vehicle. The matching CVT continuously variable transmission (analog 10th gear) provides a smooth shifting experience and good fuel economy.

To sum up, Autohome owners have praised the appearance of the Asian Dragon, believing that it is not only unique and full of charm, but also stylish and atmospheric with its sharp front face and smooth lines. Owners are even more amazed by the proportions and coordination of the body, saying that it is visually attractive. This evaluation undoubtedly emphasizes the Asian Dragon as a striking model, which not only meets the aesthetic needs, but also reflects its excellent design concept in the details.

In order to let the fans "*** on top", Lantu Car used a "****** method"

6On the weekend of 19th, the opening of Wuhan Jiangchen Tian Street, the largest and highest-positioned "city-level Chaoshang Cultural and Social Cultural Center" in Central China, and the first TOD urban complex in Wuhan, attracted countless citizens to "clock in". Interestingly, many parents who came to see the "HELLO KITTY Modern Era China First Exhibition" were "planted grass" by the Lantu space at the entrance. Many children surrounded the Lantu FREE (parameter Shu picture) (priced 313,600 – 333,600 yuan) that was listed at the same time that day and refused to leave for a long time.

The free space on the second floor is even more lively: not only does it gather a large number of customers and fans, but it also holds a unique "dialogue": Lu Fang, CEO of Lantu Automobile, Lantu Automobile CBO Lei Xin and other company executives incarnate as "product expert team MATE" to personally answer various "tricky" questions raised by booking users. The four limited-time rights announced on the spot for "Dading users" (exclusive luxury package, 3-year 0-interest car purchase, lifetime free charging and 3-year value preservation redemption) also aroused the enthusiasm of many prospective car owners, and the scene was very active.

Automotive News Agency understands that such communication will be just the beginning. With the opening of 7 Lantu spaces in 6 cities at the same time on June 16, Lantu has opened 14 directly-operated stores in 10 cities across the country. It is expected that by the end of this year, more than 50 direct sales channels will be established across the country, covering 20 core cities. At this time, Lantu Auto executives will also rush to these cities to listen to the voices of local users and make friends with users.

Such a down-to-earth scene, I believe that everyone will only see it in the "territory" of new car-making forces such as Tesla and NIO in the past; and Lantu FREE has made many "old drivers" in the media circle shine in terms of appearance, workmanship, and driving quality. You know, when DONGFENG MOTOR CORPORATION (hereinafter referred to as "Dongfeng Company") ‘s high-end electric brand Yoyah (referred to as "Lantu") was established on July 17, 2020, it was also complained that it was "old-fashioned" and "too traditional", and many people had doubts about whether Dongfeng Company, the "first to eat crabs" among central enterprises, "can successfully transform?" "Can it make high-end electric vehicles?"

Everyone must ask, why did the Landscape change so much in just one year?

1.

Product Power Transformation: LetLandmap is worth itusertrust

After arriving at Wuhan Tianhe Airport, when they saw that the pick-up vehicle was Lantu FREE, "Automotive News Agency" and others were quite surprised, they put forward various questions and requirements to the driver like a barrage: "This workmanship is very good, far beyond my expectations, which factory did it?" "What is the speed? 120 (km/h)? The filter shock is good, and the chassis is very solid." "If you turn on the’sports mode ‘, the triple screen will come down, right? Come on, come and experience it quickly!"

In fact, Lantu FREE, which is positioned as a "performance-level intelligent electric SUV", has already started a 40,000-kilometer long test across 13 cities in 9 provinces and opened in-depth test drives to citizens in 12 cities across the country. Of course, it dares to be so bold to let the "picky" media experience rest assured. While creating an intelligent experience that fits the user, Lantu FREE also focuses on performance, comfort and luxury. Lantu FREE provides two power solutions of extended-range electric and pure electric, with 5 driving modes, equipped with the world’s first one-piece lifting triple screen, front and rear multi-link independent suspension, air suspension and other high-end configurations. The NEDC comprehensive battery life can reach up to 860 kilometers, and the 100-kilometer acceleration is 4.5 seconds. It is the selling points such as power performance, driving comfort, and extreme control that have made many consumers choose this "new benchmark of domestic products" in smart electric vehicles.

"Automobile News Agency" learned that as of now, the "TOP5 cities" that have booked Lantu FREE are Wuhan, Shanghai, Chengdu, Beijing and Guangzhou. The first batch of users accounted for 72% of male users, 28% of female users, and 85.9% of household users. The 30-40 age group has become the "main force". In terms of models, 81.1% of users chose the extended range version without battery life anxiety, and 69% of users chose to upgrade the "exclusive luxury package" (including air suspension and panoramic canopy, etc.).

Of course, the current biggest strength of Landmap FREE still comes from Dongfeng’s strong endorsement.

Admittedly, as a player of the "national team" and a member of the "millionaire club" of one of the top three Chinese automobile groups, Dongfeng’s "voice" and popularity in the field of new energy vehicles are not as good as that of new car manufacturers and some first-mover independent brands, but what is less known is that Dongfeng is not a "new player" in the electric vehicle industry.

As early as 2001, Dongfeng established China’s first enterprise specializing in the R & D and industrialization of electric vehicles – Dongfeng Electric Vehicle Joint Stock Company (reorganized as Zhixin Technology Joint Stock Company in September 2019, referred to as "Zhixin Technology"), which has achieved many technological breakthroughs and accumulation in the core three power and other fields. In 2016, Dongfeng began to lay out the entire value chain of the three power systems, and has accumulated rich experience in production and manufacturing by supporting Dongfeng’s own brands, Dongfeng Nissan, and Dongfeng Honda within the group, and supplying Zotye, Geely, and BAIC Foton externally.

The predecessor of Landmap, the H Division, has not "built cars behind closed doors" since it was secretly established in 2018. In addition to the "technical backing" created by Zhixin Technology System and Dongfeng Corporation’s Prospective Technology Research Institute, it has also reached in-depth cooperation with top supply chain systems including Huawei, Bosch, Tianhe, and Tencent in a short period of time, building a business value community. This means that when Dongfeng Corporation officially disclosed Landmap last year, this seemingly young high-end electric vehicle brand had already fully integrated the rich experience of mature car companies and the flexible innovation mechanism of new car companies. This is different from the "play" of many traditional car companies, but coincides with the new car companies.

"We rarely say that Lantu is a car company, but a user-based enterprise. The most fundamental thing is that we want to serve users, understand their needs, and operate their needs," said Lu Fang, CEO of Lantu Automobile. "All business logic of Lantu is designed around users. Traditional car companies are more about meeting the functions of products, but now what Lantu does is to meet the needs of users, which is very different in business architecture and business logic." Because of this, as China’s "new car-making strength", Lantu Automobile naturally has its own unique feature – from the perspective of users, so that more fuel owners can accept and adapt to smart electric vehicles at a lower learning cost.

At present, the biggest advantage of smart electric vehicles to attract most fuel owners is "intelligence". In this regard, Landmap does not blindly raise the level of intelligence, but fully considers the user’s high-frequency usage scenarios, and provides the most suitable driving habits, the most commonly used, and the most convenient intelligent driving assistance functions to the owner. For example, for high-frequency scenarios such as urban congestion, high-speed cruise, and night driving, Landmap FREE provides 20 intelligent driving auxiliary features such as ACC full-speed domain adaptive cruise, LKA lane keeping assistance, and AEB automatic braking, and is equipped with the NVS night vision system that is rarely equipped with models.

During the experience of "Automotive News Agency", I noticed that during the driving process of Lantu FREE, the camera in the car will always pay attention to the driver. Once it is found that its line of sight deviates from the driving direction for a certain period of time, the VOYAH Attention Awakening Mode will activate the voice and prompt tone to remind the driver to find a rest stop for rest. Of course, the driver can also respond "I’m fine" and "I’m not tired" to disarm the warning. Although this function still has room for optimization, it is not difficult to see Lantu’s Internet thinking from it.

In response to users’ complex parking "pain points", Landmap FREE fully considers various parking scenarios, not only supports common vertical and lateral parking spaces, but also can cope with complex scenarios such as 45 ° and 60 ° oblique train spaces, ramp parking spaces, etc. It is currently the only model that supports oblique train head parking, realizing the most fully automatic parking scenarios currently covered.

"As a data-driven, technology-driven, user-driven company, what Lantu needs to do is to drive the development of the automotive industry with the most advanced technology. In this era of fierce competition, if you are not fast enough and advanced enough, you are likely to be eliminated." But at the same time, Lu Fang also stressed that Lantu and users need to create a symbiotic relationship of mutual growth, not a simple business relationship, so "we must not toss users, then we can only toss ourselves. Although a technology may not be 100% safe, we must strive to achieve 99.9% or even higher security, otherwise how can consumers feel at ease? Maybe colleagues always say that I am not very traditional, but when it comes to security, I am really traditional."

It is worth mentioning that in terms of autonomous driving technology, which has attracted much attention recently, Lu Fang promises to open data to users in the future (under the premise of ensuring the privacy of car owners), and to conduct product co-creation: "But we can’t treat users as our experimenters, which is unfair to users. We have plans for future autonomous driving technology, but on the one hand, it depends on laws and regulations, and on the other hand, it also depends on the real needs of users. If some driving technology can reduce your driving burden, I think it may be necessary, but let you completely increase the burden on your heart. When I’m driving, you always remind me that I don’t think it’s a good experience. So we still have to start from the perspective of experience."

"At present, we are in an era when domestic products are just right, and Chinese brands are experiencing the rise of brands. We hope to provide users with products and services that are’value for money, price is credible, buy without regret, use without worry, empower life, and harvest friendship ‘.’" For Lantu FREE, Lu Fang’s confidence is not without reason: as the official mass production of Lantu FREE on June 30 is approaching, the Lantu automotive team is working with partners to carry out a series of measures such as exquisite Quality Standard matching, special characteristics full guarantee risk investigation and confirmation, mass production supervision, and key supplier partners’ in-factory promotion activities to ensure high-quality delivery of parts during mass production. Whether Lantu can "become famous in one battle" can be described as this move.

2.

Transforming service capabilities: turning every user into a partner

"The development of China’s auto industry is inseparable from the growth of consumers. Now consumers, especially new energy owners, have a lot of thinking and research on cars, technologies, and future travel lifestyles. Their expectations are not only high-quality products and advanced technologies, but also hope that car companies will eventually bring a new lifestyle to them." Lei Xin, CBO of Lantu Automobile, pointed out in an interview with Automotive News Agency that Lantu’s goal of reaching users through "direct sales mode + APP" is being realized. While it can meet user requests faster, some "die-hard fans" have participated in the development process of new models and put forward many useful suggestions.

In fact, in the eyes of many media, thanks to the strong endorsement of Dongfeng Company, the product strength is not the shortcoming of Lantu, a young brand – after all, the Lantu FREE of extended range and pure electric "dual support" is born to solve the anxiety of users. It is also very targeted in the dimensions of intelligence, performance and comfort, and the whole series comes standard with many luxury equipment, which is comparable to a number of competitors. But in shaping brand perception and building a good reputation among seed users, Lantu does have a lot of homework to do.

To this end, like many new car-making forces, Landmap has built a marketing system and after-sales services system based on the direct sales model. Focusing on the core of "user-centered", Landmap has built APP and Mini Program online, established flagship stores, Landmap space, delivery service center, and full-function user center offline. Four different forms of stores, and built a product expert team MATE listens to users’ voices in direct-operated stores across the country. Later, Landmap will also meet user requests through continuous OTA.

Careful netizens will notice that the "C position" on the first floor of many popular shopping malls is no longer the "exclusive" of luxury or fast-moving consumer goods stores. Tesla, NIO, Ideal, Xiaopeng and many other smart electric vehicle brands have followed, together with Apple, Huawei, Xiaomi and other 3C products, becoming the new "image responsibility" in the market. However, Lantu is still the first to create a high-end new energy brand among traditional car companies and adopt a direct sales model.

In terms of location selection of direct-operated stores, Lei Xin revealed that on the basis of full insight into consumer needs, Lantu follows the three elements of "being closer to the user’s home life circle, closer to the user’s entertainment business circle, and closer to the user’s work circle": "Affected by urban development, now 4S stores are slowly turning to the suburbs, making it inconvenient for users to see and buy cars. Opening urban spaces in high-end supermarkets can be close to the user’s living radius and life circle, and there is no need to go to the suburbs. For example, Shanghai Moon Bay Lantu Space is in a community, at the user’s doorstep. We can bring users the most convenient and favorite brand experience and communication method in a way that is more convenient for users to contact."

"Users can conveniently learn about information and products online, and quickly experience offline, so that users can communicate with us as partners, relatively easily. Everyone sits and drinks coffee, and is tired and rests to read books. In a sense, visiting direct-operated stores can become a way of life, rather than simply completing a purchase as before. Compared with traditional 4S stores, this is actually a fundamental change." Lei Xin also stressed that under the new retail model, the information and services related to products (vehicles and car services, etc.) must be direct, transparent, unified and of high quality. " For example, after users place an order with one click on the official Lantu Auto APP, they can see the whole process information of the vehicle from order generation, matching, manufacturing, logistics, and delivery. They can track it at any time and control it freely. "

Different from the traditional one-time buying and selling relationship, what Lantu Auto hopes for is long-term interaction, which is to cultivate "seed users" and cultivate the core user circle. "Seed users" are the first ripples that Lantu provokes in the market. They follow from Lantu’s first product and become strong advocates, and then the ripples of the second and third circles come. As Lantu Auto adheres to "user orientation" and "co-construction and sharing", actively responds to user concerns, and actively builds a platform for customer engagement of Lantu affairs, private domain traffic is increasing, and user identity is also forming.

It is worth mentioning that Lantu’s direct sales model also has a great "ambition" that is, like the founder of the 3C direct sales model – Apple Store, "it reflects the employee-centered corporate culture, attaches great importance to employee benefits and satisfaction, and then cultivates every employee into a’evangelist ‘of the brand."

"All customers who come to the store will feel our humility (Modest), positivity (Active), teamwork (Teamworking) and vitality (Energetic). We look forward to becoming partners on each other’s life path with customers, and jointly create a beautiful taste life with true zero anxiety." The head of Lantu Space Shanghai Ruihong Tiandi Moon Bay Store previously introduced to Auto News Agency: MATE culture is not only to reshape the relationship between employees, but also to become like-minded partners. More importantly, it can bring high-quality warm services to users, so that the brand value and product value of Lantu can be truly reflected through user operation. " Our entire team is building the Landmap MATE partner culture, which is to establish a relationship like classmates, family, and friends. When we are together, we don’t just come to do a job, it is best if you are the sales champion. I hope that everyone can make friends here, like family, discuss things together, learn together, make progress together, help each other, and realize value together. "

Write at the end

"The concept of user enterprise is easy to be accepted by everyone, but it is still very difficult to really achieve it." Unexpectedly, Lei Xin also put forward this request before the end of the interview: "I don’t have enough time to communicate today, but I still hope that everyone can give any opinions and suggestions on the product and experience link." For the future scale of the company and the market share of the product, Lantu neither talked about the vision nor "painted a big cake" (the only small goal is also very frank, that is, after the delivery of Lantu FREE, the sales volume will exceed 10,000 units quickly), but as a year ago, as far as possible to collect the most authentic views of prospective owners, potential customers and the media (even welcome "complain").

In the opinion of Automotive News Agency, it is this professional, honest and pragmatic attitude that subtly changes everyone’s opinion of Lantu – making more and more people in the industry start to look forward to it, and making more and more consumers willing to try Lantu FREE to see how much surprise it can bring.

– END –

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Buick Envision S: Everything has been upgraded on the outside, and the power remains the same.

A few days ago, SAIC-GM Buick’s new model – 2024 Envision S. As a mid-term model, the 2024 Envision S is finally no longer a small upgrade, but a major overhaul of the appearance and interior. I heard that the product power has also been greatly improved, but the entry threshold has also increased by 5,000 yuan, and the market guide price is 214,900 yuan – 239,900 yuan range. Let’s take a look at the changes in the new car!

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Appearance

The 2024 Envision S rejects the design style of the 2023 model. The new model features a split headlight set, and the upward-sloping narrow daytime running lights are matched with arched ribs on the hood, which brings a sense of power to the front. At the same time, the logo in the middle of the front is also refreshed. The middle net shape has become more open, with a blackened woven mesh shape and matte trims on both sides to increase the momentum and appear to have a certain degree of tension. The front lip is also hemmed with chrome trim to further enhance the sporty feeling, and the overall style is more inclined to the Buick tram series. The posture on the side of the body is more rhythmic, with a segmented waist line and multi-spoke wheels. The taillight shape echoes the front face.

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In terms of size, the 2024 Envision S is positioned as a medium-sized SUV, with a length, width and height of 4641/1883/1638 (1647) mm, respectively. Compared with the 2023 model’s 4662mm length, the new model is shortened by 21mm, but the 2779mm wheelbase is still the same as the 2023 model, so this change in length does not affect the ride space in the car.

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Interior

When it comes to the interior, the 2024 Envision S is not sloppy. It adopts the latest family-style design, with a new three-frame, 30-inch integrated curved screen and Huaiblock design, and the sense of technology is instantly released. The new car is equipped with Buick eConnect intelligence system, and is equipped with 8155 smart chips, vehicle to everything, CarPlay, CarLife mobile phone interconnection functions, which improves the intelligent experience a lot. At the same time, the car is also equipped with 121-color ambient lights.

In terms of smart driving, it is equipped with the new eCruise intelligent driving assistance system, which enjoys 10 L2-level intelligent driving auxiliary features such as full-speed adaptive cruise, AEB automatic emergency braking, and LKA lane keeping assistance. The top version also adds lane centering, traffic sign recognition, and the third-generation APA automatic parking assistance system.

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power

The 2024 Envision S offers 1.5T and 2.0T power configurations, both of which also join the 48V light hybrid system. Among them, the 1.5T model is still equipped with a maximum power of 155kW, and the 2.0T model is equipped with a maximum power of 174kW, both of which match the 9AT gearbox. The power performance of the new model is still so strong and easy to drive, and it also has good fuel economy. The WLTC operating condition of the 1.5T model has a combined fuel consumption of 7.3L/100km; the WLTC operating condition of the 2.0T model has a combined fuel consumption of 7.23L/100km. The most important thing is to "drink" No. 92 gasoline, which is really fragrant.

Car comparison

2024 Envision S launched a total of 3 models, the entry price of 214,900 yuan, with the middle version with the same 1.5T + 9AT + 48V power combination, compared with the two, the middle version of the increase in the electric trunk, front mobile phone wireless charging, leather seats, the main and co-pilot 4, front seat heating, 121 color ambient light, the price also increased by 8000 yuan.

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Let’s take a look at the top version, equipped with 2.0T + 9AT + 48V power combination, faster acceleration response and lower fuel consumption. Compared with the middle version, the high version has configuration, lane centering, traffic sign recognition and the third-generation APA automatic parking assistance system protection, 3 more cameras, 8 more radars and 4 new millimeter wave radars, that is to say, the care in smart driving is more complete, of course, the price has also increased a lot, to add 17,000 yuan on the basis of the middle version, the price is 239,900 yuan.

Love Review

Although the new energy market is in deep trouble, it has not weakened the sales of fuel vehicles, especially SUV models. In the recent rankings, fuel SUVs still have the upper hand. Among the many joint venture brands, Buick Envision is also deeply loved by many consumers because of its reputation and product strength. Buick’s choice to launch 2024 Envision S models during this time period may be a normal decision, but the price positioning is not dominant among the same models.

Restaurants, hotels, and taxis in Mangshi, Yunnan have resumed work, and Mangshi is "busy"

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Since the COVID-19 epidemic spread across the country, Mangshi 420,000 people responded to the call, factories and enterprises stopped work and production, the catering service industry and tourist attractions closed their doors to thank customers, and taxis and online car-hailing idle parking lots. The whole city has united to defend the pure land of Mangshi. With the positive improvement of the epidemic prevention and control situation, all walks of life in the city have once again responded to the new call, resumed work and production, and opened their doors to welcome customers. This small border town, which has been quiet for more than a month, has begun to "busy" again.

According to Wang Ping, director of the office of Yunnan Mengbana West Treasure Garden Co., Ltd., since the resumption of work, Menghuan Golden Pagoda has been visited by tourists one after another. Disinfection is carried out twice a day in the scenic spot, and epidemic prevention and control knowledge and prevention and control instructions are affixed in a conspicuous place. Tourists entering and leaving must check their body temperature to ensure the safety of tourists and tourist places.

People take food as their heaven. For Mangshi people, it is a real expectation for everyone to be able to eat breakfast and snacks full of Mangshi characteristics. During the first-level emergency response to the COVID-19 epidemic in Yunnan Province, only a small number of restaurants and snack bars in Mangshi were open, and they had to take out. Although the taste is not bad, there is always a little less feeling. Since February 22, many restaurants, restaurants and snack bars in Mangshi have been open one after another, and they have provided on-site dining services, which has really relieved the cravings of many people.

Lin Fuwei, the owner of Wagangzhai Hotel, told reporters that the hotel has been open for three to four days, disinfecting once in the morning and evening, and urging chefs and staff to wear masks, wash their hands frequently for disinfection, etc., hoping that the epidemic will end soon, and everyone can take off the masks and return to the same life as before.

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Restaurants, hotels, and taxis have resumed work

The hotel is a highly concentrated area, and in order to ensure the health and safety of guests, the epidemic prevention measures are also more stringent.

Li Minglian, chairperson of Jiangdong Hotel, told reporters that the hotel requires employees to fill out a health commitment letter and requires self-isolation for 14 days for employees returning from outside the state. The hotel also stocks emergency supplies such as disinfectant and masks, and also disinfects one guest at a time. Guests have arrived one after another since its opening.

Along with restaurants, hotels and hotels, there is also "Xiao Huang" – taxis and online ride-hailing. This makes the streets of Mangshi lively again.

According to Guo Jiayu, deputy manager of Mangshi Branch of Dehong Transportation Group, due to the large number of people in contact with taxis and online car-hailing, in addition to the fixed 8-hour disinfection, real-time disinfection of the vehicle touch area (armrests, seats, door handles) is also carried out at any time. In addition to the daily work of the driver to check the body temperature, the exchange shift should also be checked to ensure the safety of drivers and passengers.

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Restaurants, hotels, and taxis have resumed work

The beautiful Mangshi is gradually recovering its former vitality. But the epidemic is not over yet, and the resumption of work and production cannot forget epidemic prevention and control. The general public should wear masks when entering and leaving public places, pay attention to washing hands frequently, ventilate more, and do a good job of self-protection. At the same time, they are also responsible for others.

Dark clouds can’t cover the rising sun, and epidemics can’t stop the coming of spring. I believe that in the near future, Mangshi will usher in a more beautiful and "busy" time.

Liu Shishi, Angelababy and Tang Yan: Three female stars focus on revealing the inside story!

The opening of Liu Shishi’s new drama "One Mind Close the Mountain" rekindled the popularity of "85 Flowers", but it also caused a lot of controversy. Whether it’s the interpretation in the play or the scriptwriting and publicity outside the play, it’s embarrassing for this play. Controversy was inevitable from the beginning, from the arrangement of the position to the plot and drama, and then to other aspects, which led to the drama being disturbed after its launch. Although it should have been an opportunity for Liu Shishi to get rid of the downturn of "85 Flowers", it failed in the end.

Although Liu Shishi’s popularity and influence still exist, so that her light in the entertainment circle is still dazzling, but the lack of an outstanding masterpiece, so that her future road is still full of bumps. The most painful thing at the moment is Angelababy, the representative of 85 flowers. A "crazy horse show" incident completely changed her life track, so far her account has been banned, and all activities have come to a standstill, becoming the first one among the 85 flowers to fall. In the past two years, Angelababy has mainly relied on variety shows to maintain its popularity. Although it has continuously introduced new works and actively tried to transform itself, it has made some achievements, but it has not yet stabilized.

Whether it’s Skyscraper or Wind Rises in Longxi, Angelababy’s progress is obvious. She is no longer a simple vase, but an actress with shaping and expressive force. However, she still failed to persist, and in a flash she returned to the old road, and filmed such heartbreaking works as What Love Should Be, Twilight Heart Agreement, and Dust Margin. What is even more surprising is that she was involved in the "Crazy Horse Show Storm" and finally paid a huge price and withdrew from the competition ahead of schedule. She was not good at performing in 85 flowers, but later relied on the "Run" program to maintain her popularity, and at the same time showed her determination to transform, but it was disappointing in the end.

Her change is not thorough and decisive enough, and she always swings from side to side, which leads to frustration in her career and is difficult to recover in a short time. Similar to Angelababy, there is Yang Mi, who has also returned to the old road while undergoing transformation, while relying on variety shows to maintain her popularity. However, it was obvious that she was not reconciled, so when the announcement of the new drama Harbin 1944 caused controversy, she published a determined blog post. She said that as an actor, shaping the role is the primary task. In this era, real talent will never be concealed, and the order of names should also give way to the role. It can be seen that she is eager to prove her strength.

Tang Yan: The revival of performing arts In the new year, entertainment works emerge in an endless stream, and both movies and TV plays show different styles. "There is nothing that can’t be solved by a hot pot" was originally scheduled, but it was suddenly changed to May Day, which made people full of expectations and variables. However, this year, she has a new book, which is just the right time to show her strength. However, before that, Tang Yan had already taken the lead in making her mark, and stood out ahead of time, becoming the outstanding actor of her generation.

Tang Yan has been appearing in variety shows like a tool man in the past year, bring disgrace to oneself, but at the end of the year and the beginning of the year, he successfully turned over and took the lead in breaking through! For this play, Tang Yan didn’t take another play for three years. She worked hard and polished hard, and was carefully guided by director Wong Kar-wai, and finally proved herself by virtue of her strength. After eight years, Tang Yan finally has a highly acclaimed work again. "Flowers" scored a high score of 8.1 on Douban. For Tang Yan, this drama is the best in her acting career for more than ten years.

In Flowers, Tang Yan and the role Miss Wang are perfectly integrated, showing a graceful and lifelike image. Although playing the role of a migrant worker in the workplace, it has given her more tenacious vitality. Tang Yan showed the external and internal charm of the role through her free performance, which made the audience crazy, distressed by her experience, sighed for her pain, cheered for her cry and cheered for her struggle. She finally chose to start her own business independently, proved herself and became her own support. After going through the stage of getting married and having children, Tang Yan once fell into silence, but obviously she was not content with it.

It took her three years to shoot a work. She just wanted to prove that she is still an excellent actress. Although she is over sixty years old, she has not lost her acting skills. Although she almost destroyed her image through variety shows in 2023, at the end of the year, she finally turned over successfully with Flowers, which proved herself and gave a blow to those who ignored her. Born in 1985, she once again glowed with new brilliance. After 90 s and 95 s, they have become the backbone of the entertainment industry, and they are also emerging after 00, and the golden age of actors born in 1985 has long passed.

After experiencing various events such as marriage, having children and divorce, they have quietly fallen behind. Obviously, however, they are not willing to be silent. Although they have entered middle age, their ambitions are still there, and they are all eager to win a place for themselves in the new stage. However, the reality is cruel, and a little carelessness may lead to failure. In today’s era, to achieve lasting success, the key still lies in personal strength and works created.

Award-winning publicity of the first socialist core values theme microfilm (micro-video) collection and exhibition activity in Guizhou Province

 

In order to cultivate and practice the socialist core values, the Propaganda Department of Guizhou Provincial Party Committee, the Network Information Office of Guizhou Provincial Party Committee and Guizhou Provincial Radio and Television Bureau jointly hosted the first collection and exhibition of the theme micro-film (micro-video) of socialist core values in Guizhou Province. After the initial evaluation, re-evaluation and final evaluation, the list of winning works and organizational awards will be publicized.

 

Publicity time: December 19th to December 25th, 2023.

 

Tel: 0851-85377537,

 

0851-85893109 (fax)

 

Email: shzyhxjzg2023@126.com

 

If you have any objection during the publicity period, please reflect it in writing and provide relevant supporting materials. Reflect the situation must be objective and true, materials that reflect the situation in the name of the unit need to be stamped with the official seal of the unit, and materials that reflect the situation in the name of individuals should be real names and provide effective contact information.

 

Attachment: List of Award-winning Works and Organization Awards of the First Socialist Core Values Theme Microfilm (Microfilm) in Guizhou Province

 

First prize (2 movies in total, 1 micro-movie and 1 micro-video)

 

 

Second prize (4 movies, 2 micro movies and 2 micro videos)

 

 

Third prize (6 movies, 3 micro movies and 3 micro videos)

 

 

Excellence Award (8 movies, 4 micro movies and 4 micro videos)

 

 

Outstanding Organization Awards (8)

 

 

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Source: Dynamic Guizhou

 

Editor: Liu LuEditor: Zhou Ning Editor: Xu Fei